Candida aurisBloodstream Infections in Russia

Candida auris-a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases ofC. aurisbloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread ofC. auris. The South Asian lineage of the studied strains was indicated by K143R substitution inERG11gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates fromC. auriscandidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate inC. aurisbloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication ofC. aurisfrom blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management ofC. aurisinfections are needed.