Sun exposure and multiple sclerosis risk in Norway and Italy: The EnvIMS study

被引：66

作者：

Bjornevik, Kjetil ^{[1
,2
]}

Riise, Trond ^{[1
,2
]}

Casetta, Ilaria ^{[3
]}

Drulovic, Jelena ^{[4
]}

Granieri, Enrico ^{[3
]}

Holmoy, Trygve ^{[5
,6
]}

Kampman, Margitta T. ^{[7
,8
]}

Landtblom, Anne-Marie ^{[9
]}

Lauer, Klaus ^{[10
]}

Lossius, Andreas ^{[5
,11
]}

Magalhaes, Sandra ^{[12
]}

Myhr, Kjell-Morten ^{[2
,13
]}

Pekmezovic, Tatjana ^{[14
]}

Wesnes, Kristin ^{[1
,2
]}

Wolfson, Christina ^{[15
]}

Pugliatti, Maura ^{[1
,16
]}

机构：

[1] Univ Bergen, Dept Global Publ Hlth & Primary Care, N-5020 Bergen, Norway

[2] Haukeland Hosp, Norwegian Multiple Sclerosis Competence Ctr, Dept Neurol, Bergen, Norway

[3] Univ Ferrara, Sect Clin Neurol, Dept Biomed & Surg Sci, I-44100 Ferrara, Italy

[4] Univ Belgrade, Fac Med, Clin Neurol, Belgrade 11001, Serbia

[5] Univ Oslo, Fac Med, Inst Clin Med, N-0316 Oslo, Norway

[6] Akershus Univ Hosp, Dept Neurol, Lorenskog, Norway

[7] Univ Tromso, Dept Clin Neurol, N-9001 Tromso, Norway

[8] Univ Hosp North Norway, Dept Neurol, Tromso, Norway

[9] Linkoping Univ, Dept Clin & Expt Med, UHL, Div Neurol,Cty Council, S-58183 Linkoping, Sweden

[10] Griesheim, Darmstadt, Germany

[11] Natl Hosp Norway, Oslo Univ Hosp, Inst Immunol, Oslo, Norway

[12] McGill Univ, Dept Epidemiol & Biostat & Occupat Hlt, Montreal, PQ H3A 2T5, Canada

[13] Univ Bergen, Dept Clin Med, KG Jebsen Ctr MS Res, N-5020 Bergen, Norway

[14] Univ Belgrade, Fac Med, Inst Epidemiol, Belgrade 11001, Serbia

[15] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H3A 2T5, Canada

[16] Univ Sassari, Dept Clin & Expt Med, I-07100 Sassari, Italy

来源：

MULTIPLE SCLEROSIS JOURNAL | 2014年 / 20卷 / 08期

关键词：

Multiple sclerosis; sun exposure; vitamin D; sunscreen; epidemiology; VITAMIN-D PRODUCTION; ULTRAVIOLET-RADIATION; PREVALENCE; MS; ADOLESCENCE; CHILDHOOD; PROVINCE; EUROPE; TRIAL;

D O I：

10.1177/1352458513513968

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objectives: The objective of this paper is to estimate the association between multiple sclerosis (MS) and measures of sun exposure in specific age periods in Norway and Italy. Methods: A total of 1660 MS patients and 3050 controls from Italy and Norway who participated in a multinational case-control study (EnvIMS) reported sun habits during childhood and adolescence. Results: A significant association between infrequent summer outdoor activity and increased MS risk was found in Norway and in Italy. The association was strongest between the ages of 16 and 18 years in Norway (odds ratio (OR) 1.83, 95% confidence interval (Cl) 1.30-2.59), and between birth and age 5 years in Italy (OR 1.56, 95% CI 1.16-2.10). In Italy a significant association was also found during winter (OR 1.42, 95% Cl 1.03-1.97). Frequent sunscreen use between birth and the age of 6 years was associated with MS in Norway (OR 1.44, 95% Cl 1.08-1.93) after adjusting for outdoor activity during the same period. Red hair (OR 1.67, 95% Cl 1.06-2.63) and blonde hair (OR 1.36, 95% CI 1.09-1.70) were associated with MS after adjusting for outdoor activity and sunscreen use. Conclusion: Converging evidence from different measures underlines the beneficial effect of sun exposure on MS risk.

引用

页码：1042 / 1049

页数：8

共 36 条

[31] Risk of MS is not associated with exposure to crude oil, but increases with low level of education [J].