Multi-vitamin supplementation blunts the circulating IL-6/IL-10 ratio increase after knee arthroplasty: A randomized, double-blind, placebo controlled study

被引:5
作者
Barker, Tyler [1 ,2 ]
Henriksen, Vanessa T. [3 ]
Rogers, Victoria E. [3 ]
Trawick, Roy H. [3 ,4 ]
Momberger, Nathan G. [3 ,4 ]
Rasmussen, G. Lynn [3 ,4 ]
机构
[1] Intermt Healthcare, Precis Genom, 383 West Vine St,Suite 300, Murray, UT 84123 USA
[2] Univ Utah, Dept Nutr & Integrat Physiol, Salt Lake City, UT 84112 USA
[3] Intermt Healthcare, Orthoped Specialty Hosp, Murray, UT 84107 USA
[4] Intermt Healthcare, Orthoped Specialty Clin, Murray, UT 84107 USA
关键词
IL-6; IL-10; Vitamin D; Vitamin C; Knee arthroplasty;
D O I
10.1016/j.cyto.2021.155435
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Circulating interleukin (IL)-6 and IL-10 concentrations can be elevated following the surgically induced trauma of total knee arthroplasty (TKA). An exaggerated increase in IL-6 relative to IL-10 (i.e., IL-6/IL-10 ratio) associates with trauma severity and indicative of pro-inflammatory predominance. Although various vitamins and minerals alter individual IL-6 and IL-10 concentrations in the blood, surprisingly, it is unknown if a multi-vitamin supplement alters the IL-6/IL-10 ratio during the systemic inflammatory response following TKA. The objective of this study was to identify if a multi-vitamin with mineral supplement taken prior to alters the circulating IL-6/ IL-10 ratio following total knee arthroplasty (TKA). This study consisted of a randomized, double-blind, placebo controlled design. Twenty-one subjects undergoing elective, primary, unilateral TKA were randomly assigned to a placebo (PL, n = 11) or multi-vitamin with mineral supplement (MV, n = 10). Supplements were taken daily starting approximately 6-weeks prior to surgery. Supplements were not taken the day of surgery or during inpatient care 2-days after surgery. Circulating IL-6, IL-10, high-sensitivity CRP (hsCRP), vitamin C (ascorbic acid (AA)), vitamin D (25-hydroxyvitamin D (25(OH)D)), and vitamin E (alpha-tocopherol (alpha T)) concentrations were measured in fasting blood draw samples obtained similar to 6-weeks prior to surgery (and before starting supplementation), the morning of surgery, and 24-hours and 48-hours after surgery. MV supplementation tended to increase serum 25(OH)D and significantly increased plasma AA and plasma alpha T before surgery without mitigating the postoperative IL-6 and hsCRP increases. However, the post-operative increase in the serum IL-6/IL-10 ratio after surgery was significantly blunted in the MV group. Based on these findings, we conclude that a multi-vitamin with mineral supplement taken daily for several weeks before surgery might reduce the pro-inflammatory predominance after TKA. Future research confirming or refuting the novel data presented herein is needed.
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页数:5
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