A non-intrusive evaluation method for tumor-targeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging

被引：8

作者：

Liu, Hao ^{[1
,2
]}

Marquez, Rebecca T. ^{[2
]}

Wu, Xiaoqing ^{[2
]}

Li, Ke ^{[3
]}

Vadlamani, Shweta ^{[2
]}

Li, Song ^{[4
]}

Wang, Ya ^{[5
]}

Xu, Liang ^{[2
,6
]}

Wu, Daocheng ^{[5
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmaceut, Luzhou City 646000, Sichuan, Peoples R China

[2] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

[3] Xian Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Brain Disorders, Shaanxi Key Lab Ischem Cardiovasc Dis, Xian 710049, Shaanxi, Peoples R China

[4] Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Sch Pharm,Canc Inst, Pittsburgh, PA 15261 USA

[5] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Educ Minist, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China

[6] Univ Kansas, Canc Ctr, Dept Radiat Oncol, Kansas City, KS USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 31期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

ENHANCED PERMEABILITY; BREAST-CANCER; DELIVERY; DOXORUBICIN;

D O I：

10.1039/c9tb00882a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in vivo without culling animals.

引用

页码：4751 / 4757

页数：7

共 50 条

[41] Imaging tumor angiogenesis in breast cancer experimental lung metastasis with positron emission tomography, near-infrared fluorescence, and bioluminescence
Yin Zhang
Hao Hong
Tapas R. Nayak
Hector F. Valdovinos
Duane V. Myklejord
Charles P. Theuer
Todd E. Barnhart
Weibo Cai
Angiogenesis, 2013, 16 : 663 - 674
[42] Near-infrared quantum-dot-based non-invasive in vivo imaging of squamous cell carcinoma U14
Cao, Yu'an
Yang, Kai
Li, Zhigang
Zhao, Cheng
Shi, Chunmeng
Yang, Jia
NANOTECHNOLOGY, 2010, 21 (47)
[43] Comparison of Tumor Non-specific and PD-L1 Specific Imaging by Near-Infrared Fluorescence/Cerenkov Luminescence Dual-Modality In-situ Imaging
Zhang, Linhan
Zhao, Lianmeng
Lin, Xue
Zhao, Sheng
Pan, Wenbin
Wang, Dandan
Sun, Zhongqi
Li, Jinping
Liang, Zonghui
Zhang, Rongjun
Jiang, Huijie
MOLECULAR IMAGING, 2024, 23
[44] Liposomal Encapsulation of a Near-Infrared Fluorophore Enhances Fluorescence Quenching and Reliable Whole Body Optical Imaging Upon Activation In Vivo
Tansi, Felista L.
Rueger, Ronny
Rabenhold, Markus
Steiniger, Frank
Fahr, Alfred
Kaiser, Werner A.
Hilger, Ingrid
SMALL, 2013, 9 (21) : 3659 - 3669
[45] Evaluation of Temperature-Sensitive, Indocyanine Green-Encapsulating Micelles for Noninvasive Near-Infrared Tumor Imaging
Kim, Tae Hee
Chen, Yongping
Mount, Christopher W.
Gombotz, Wayne R.
Li, Xingde
Pun, Suzie H.
PHARMACEUTICAL RESEARCH, 2010, 27 (09) : 1900 - 1913
[46] A near-infrared fluorescence-based surgical navigation system imaging software for sentinel lymph node detection
Ye, Jinzuo
Chi, Chongwei
Zhang, Shuang
Ma, Xibo
Tian, Jie
ADVANCED BIOMEDICAL AND CLINICAL DIAGNOSTIC AND SURGICAL GUIDANCE SYSTEMS XII, 2014, 8935
[47] Synthesis and evaluation of Cy5.5-Rit tracer for specific near-infrared fluorescence imaging of sentinel lymph node
Li, Nan
Zhu, Hua
Li, Yan
Wang, Jing
Yang, Zhi
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (17) : 4233 - 4236
[48] Perfusion-based fluorescence imaging method delineates diverse organs and identifies multifocal tumors using generic near-infrared molecular probes
Miller, Jessica
Wang, Steven T.
Orukari, Inema
Prior, Julie
Sudlow, Gail
Su, Xinming
Liang, Kexian
Tang, Rui
Hillman, Elizabeth M. C.
Weilbaecher, Katherine N.
Culver, Joseph P.
Berezin, Mikhail Y.
Achilefu, Samuel
JOURNAL OF BIOPHOTONICS, 2018, 11 (04)
[49] Dextran based pH-activated near-infrared fluorescence nanoprobe imaging the acidic compartments in cancer cells
Li, Cong
Li, Kai
Yan, Huihui
Li, Guanghui
Xia, Jinsong
Wei, Xunbin
CHEMICAL COMMUNICATIONS, 2010, 46 (08) : 1326 - 1328
[50] Metal-Organic Frameworks@Polymer Composites Containing Cyanines for Near-Infrared Fluorescence Imaging and Photothermal Tumor Therapy
Wang, Weiqi
Wang, Lei
Liu, Shi
Xie, Zhigang
BIOCONJUGATE CHEMISTRY, 2017, 28 (11) : 2784 - 2793

← 1 2 3 4 5 →