A non-intrusive evaluation method for tumor-targeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging

被引：8

作者：

Liu, Hao ^{[1
,2
]}

Marquez, Rebecca T. ^{[2
]}

Wu, Xiaoqing ^{[2
]}

Li, Ke ^{[3
]}

Vadlamani, Shweta ^{[2
]}

Li, Song ^{[4
]}

Wang, Ya ^{[5
]}

Xu, Liang ^{[2
,6
]}

Wu, Daocheng ^{[5
]}

机构：

[1] Southwest Med Univ, Sch Pharm, Dept Pharmaceut, Luzhou City 646000, Sichuan, Peoples R China

[2] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA

[3] Xian Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Brain Disorders, Shaanxi Key Lab Ischem Cardiovasc Dis, Xian 710049, Shaanxi, Peoples R China

[4] Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Sch Pharm,Canc Inst, Pittsburgh, PA 15261 USA

[5] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Educ Minist, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China

[6] Univ Kansas, Canc Ctr, Dept Radiat Oncol, Kansas City, KS USA

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 31期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

ENHANCED PERMEABILITY; BREAST-CANCER; DELIVERY; DOXORUBICIN;

D O I：

10.1039/c9tb00882a

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in vivo without culling animals.

引用

页码：4751 / 4757

页数：7

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