A non-intrusive evaluation method for tumor-targeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging

被引：8
|
作者：
Liu, Hao [1 ,2 ]
Marquez, Rebecca T. [2 ]
Wu, Xiaoqing [2 ]
Li, Ke [3 ]
Vadlamani, Shweta [2 ]
Li, Song [4 ]
Wang, Ya [5 ]
Xu, Liang [2 ,6 ]
Wu, Daocheng [5 ]
机构：
[1] Southwest Med Univ, Sch Pharm, Dept Pharmaceut, Luzhou City 646000, Sichuan, Peoples R China
[2] Univ Kansas, Dept Mol Biosci, Lawrence, KS 66045 USA
[3] Xian Med Univ, Inst Basic & Translat Med, Shaanxi Key Lab Brain Disorders, Shaanxi Key Lab Ischem Cardiovasc Dis, Xian 710049, Shaanxi, Peoples R China
[4] Univ Pittsburgh, Ctr Pharmacogenet, Dept Pharmaceut Sci, Sch Pharm,Canc Inst, Pittsburgh, PA 15261 USA
[5] Xi An Jiao Tong Univ, Sch Life Sci & Technol, Educ Minist, Key Lab Biomed Informat Engn, Xian 710049, Shaanxi, Peoples R China
[6] Univ Kansas, Canc Ctr, Dept Radiat Oncol, Kansas City, KS USA
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2019年 / 7卷 / 31期
基金：
美国国家卫生研究院; 中国国家自然科学基金;
关键词：
ENHANCED PERMEABILITY; BREAST-CANCER; DELIVERY; DOXORUBICIN;
D O I：
10.1039/c9tb00882a
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
We developed a novel evaluation method for tumor-targeting characteristics of nanomedicines, average tumor-targeting index (average TTI) and "area under the tumor-targeting index-time curve" (AUTC) were established as the indicators for tumor targeting of nanomedicines based on NIR fluorescence imaging, which helps real-time monitoring of targeting ability and tumor changes in vivo without culling animals.
引用
收藏
页码：4751 / 4757
页数：7
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