CANCER The fat and the furious

被引：13

作者：

Gottlieb, Eyal ^{[1
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

来源：

NATURE | 2009年 / 461卷 / 7260期

关键词：

EXTRACELLULAR-MATRIX; TRANSFORMATION; APOPTOSIS;

D O I：

10.1038/461044a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Evidence linking metabolic alterations to cancer progression is accumulating. It seems that cancer cells must sustain their energy production and remain well fed to survive detachment from their normal habitat.

引用

页码：44 / 45

页数：2

共 10 条

[1] TIGAR, a p53-inducible regulator of glycolysis and apoptosis [J].

Bensaad, Karim ;

Tsuruta, Atsushi ;

Selak, Mary A. ;

Calvo Vidal, M. Nieves ;

Nakano, Katsunori ;

Bartrons, Ramon ;

Gottlieb, Eyal ;

Vousden, Karen H. .

CELL, 2006, 126 (01) :107-120

[2] The role of apoptosis in creating and maintaining luminal space with normal and oncogene-expressing mammary acini [J].

Debnath, J ;

Mills, KR ;

Collins, NL ;

Reginato, MJ ;

Muthuswamy, SK ;

Brugge, JS .

CELL, 2002, 111 (01) :29-40

[3] Anoikis mechanisms [J].

Frisch, SM ;

Screaton, RA .

CURRENT OPINION IN CELL BIOLOGY, 2001, 13 (05) :555-562

[4] The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C-Cdh1 [J].

Herrero-Mendez, Angel ;

Almeida, Angeles ;

Fernandez, Emilio ;

Maestre, Carolina ;

Moncada, Salvador ;

Bolanos, Juan P. .

NATURE CELL BIOLOGY, 2009, 11 (06) :747-U105

[5] Tumours with PI3K activation are resistant to dietary restriction [J].

Kalaany, Nada Y. ;

Sabatini, David M. .

NATURE, 2009, 458 (7239) :725-U61

[6] Extracellular matrix regulation of autophagy [J].

Lock, Rebecca ;

Debnath, Jayanta .

CURRENT OPINION IN CELL BIOLOGY, 2008, 20 (05) :583-588

[7] Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer [J].

Nelson, Celeste M. ;

Bissell, Mina J. .

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2006, 22 :287-309

[8] Akt-dependent transformation: there is more to growth than just surviving [J].

Plas, DR ;

Thompson, CB .

ONCOGENE, 2005, 24 (50) :7435-7442

[9] Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment [J].

Schafer, Zachary T. ;

Grassian, Alexandra R. ;

Song, Loling ;

Jiang, Zhenyang ;

Gerhart-Hines, Zachary ;

Irie, Hanna Y. ;

Gao, Sizhen ;

Puigserver, Pere ;

Brugge, Joan S. .

NATURE, 2009, 461 (7260) :109-U118

[10] Metabolic transformation in cancer [J].

Tennant, Daniel A. ;

Duran, Raul V. ;

Boulahbel, Houda ;

Gottlieb, Eyal .

CARCINOGENESIS, 2009, 30 (08) :1269-1280

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