Synthesis, spectral, thermal and insulin-enhancing properties of oxovanadium(IV) complexes of metformin Schiff-bases

被引：11

作者：

Mahmoud, Marwa A. ^{[1
]}

Zaitone, Sawsan A. ^{[2
]}

Ammar, Alaa M. ^{[3
]}

Sallam, Shehab A. ^{[3
]}

机构：

[1] Suez Univ, Fac Petr & Min Engn, Dept Sci & Math Engn, Suez, Egypt

[2] Suez Canal Univ, Dept Pharmacol & Toxicol, Fac Pharm, Ismailia, Egypt

[3] Suez Canal Univ, Dept Chem, Fac Sci, Ismailia, Egypt

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2017年 / 128卷 / 02期

关键词：

Metformin Schiff-bases; VO2+ complexes; Spectral and thermal properties; Antidiabetes mellitus; SPECTROSCOPIC CHARACTERIZATION; COORDINATION-COMPOUNDS; BIGUANIDE COMPLEXES; DIABETES-MELLITUS; VANADYL COMPLEXES; MIMETIC AGENTS; IN-VITRO; RATS; N; N-DIMETHYLBIGUANIDE; CARBOHYDRATE;

D O I：

10.1007/s10973-016-6018-1

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

A series of VO2+ complexes of Schiff-bases of metformin with each of salicylaldehyde (HL1); 2,3-dihydroxybenzaldehyde (H2L2); 2,4-dihydroxybenzaldehyde (H2L3); 2,5-dihydroxybenzaldehyde (H2L4); 3,4-dihydroxybenzaldehyde (H2L5); and 2-hydroxynaphthaldehyde (HL6) were synthesized by template reaction. The new compounds are characterized through elemental analysis, conductivity measurements, magnetic moment, IR, UV-Vis, ESR and mass spectroscopy. The complexes have square pyramidal structure with mu values of pentacoordinated vanadyl ion. TG, DTG and DTA confirm the proposed stereochemistry, and a mechanism of thermal decomposition was suggested. Mice treated with the complexes [(VOLH2O)-H-1]center dot 1A 1/2H(2)O and [(VOHLH2O)-H-4]center dot 2H(2)O showed glucose-lowering effect of 59.31, 58.79% (20 mg kg(-1)) and 64.98, 74.8% (40 mg kg(-1)) compared to metformin.

引用

页码：957 / 969

页数：13

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