Gut microbiota is associated with protection against Marek's disease virus infection in chickens

被引：16

作者：

Bavananthasivam, Jegarubee ^{[1
,2
,3
]}

Astill, Jake ^{[1
]}

Matsuyama-Kato, Ayumi ^{[1
]}

Taha-Abdelaziz, Khaled ^{[1
,4
]}

Shojadoost, Bahram ^{[1
]}

Sharif, Shayan ^{[1
]}

机构：

[1] Univ Guelph, Ontario Vet Coll, Dept Pathobiol, Guelph, ON N1G 2W1, Canada

[2] McMaster Univ, MG DeGroote Sch Med, Dept Pathol & Mol Med, Hamilton, ON L8S 4L8, Canada

[3] McMaster Univ, McMaster Immunol Res Ctr, Hamilton, ON L8S 4L8, Canada

[4] Beni Suef Univ, Fac Vet Med, Dept Pathol, Bani Suwayf 62511, Egypt

来源：

VIROLOGY | 2021年 / 553卷

基金：

加拿大自然科学与工程研究理事会;

关键词：

Marek's disease virus; Chickens; Gut microbiota; Antibiotic cocktail; Cytokines; Toll-like receptors; HOST RESPONSES; ANTIMICROBIAL RESISTANCE; ENTEROCOCCUS SPP; VIRULENCE GENES; EXPRESSION; QUANTIFICATION; INTERFERON; PRIMERS; SYSTEM;

D O I：

10.1016/j.virol.2020.10.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Marek's Disease Virus (MDV) infects chickens via respiratory route and causes lymphomas in internal organs including gastrointestinal tract. MDV infection causes a shift in the gut micmbiota composition. However, interactions between the gut microbiota and immune responses against MDV infection are not well understood. Therefore, the current study was performed to understand the effect of the gut microbiota on Marek's disease (MD) pathogenesis. The findings showed that depletion of gut microbiota increased the severity of MD in infected chickens. In addition, an increase in the transcription of interferon (IFN)-alpha, IFN-beta and IFN-gamma in the bursa of Fabricius at 4 days post-infection (dpi) was observed in the gut microbiota depleted chickens. The observations in this study shed more light on the association between the gut microbiota and MDV infection in chickens. More research is needed to explore the mechanisms of involvement of the gut micmbiota in immunity against MD in chickens.

引用

页码：122 / 130

页数：9

共 51 条

[1] Host responses in the bursa of Fabricius of chickens infected with virulent Marek's disease virus [J].