Nerve Dependence: From Regeneration to Cancer

被引:210
作者
Boilly, Benoni [1 ]
Faulkner, Sam [2 ]
Jobling, Phillip [2 ]
Hondermarck, Hubert [2 ]
机构
[1] Univ Lille, UFR Biol, F-59655 Villeneuve Dascq, France
[2] Univ Newcastle, Hunter Med Res Inst, Sch Biomed Sci & Pharm, Callaghan, NSW 2308, Australia
关键词
FIBROBLAST-GROWTH-FACTOR; PANCREATIC DUCTAL ADENOCARCINOMA; AXOLOTL AMBYSTOMA-MEXICANUM; AMPHIBIAN LIMB REGENERATION; AGGRESSIVE PROSTATE-CANCER; DIGIT TIP REGENERATION; INTESTINAL STEM-CELLS; BREAST-CANCER; BETA-BLOCKERS; PERIPHERAL-NERVE;
D O I
10.1016/j.ccell.2017.02.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Nerve dependence has long been described in animal regeneration, where the outgrowth of axons is necessary to the reconstitution of lost body parts and tissue remodeling in various species. Recent discoveries have demonstrated that denervation can suppress tumor growth and metastasis, pointing to nerve dependence in cancer. Regeneration and cancer share similarities in regard to the stimulatory role of nerves, and there are indications that the stem cell compartment is a preferred target of innervation. Thus, the neurobiology of cancer is an emerging discipline that opens new perspectives in oncology.
引用
收藏
页码:342 / 354
页数:13
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