Synthesis of Biocompatible Gelatin-functionalised Graphene Nanosheets For Drug Delivery Applications

被引：14

作者：

Chen, Guangxin ^{[1
]}

Qiao, Congde ^{[1
]}

Wang, Yang ^{[1
]}

Yao, Jinshui ^{[1
]}

机构：

[1] Qilu Univ Technol, Sch Mat Sci & Engn, Jinan 250353, Peoples R China

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2014年 / 67卷 / 10期

关键词：

OXIDE; REDUCTION; GRAPHITE; TRANSPARENT; PHASE; GAS;

D O I：

10.1071/CH13678

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gelatin-functionalised graphene nanosheets (gelatin-GNS) with good biocompatibility were successfully synthesised using gelatin as a reductant. Factors that affect the reduction of graphene oxide (GO), such as the ratio of gelatin to GO, pH, and temperature, were investigated to establish optimum reaction conditions. We found that GO was efficiently reduced by gelatin at a comparatively low temperature and a stable gelatin-GNS aqueous dispersion was formed. The as-obtained biocompatible gelatin-GNS displayed a high methotrexate (MTX) drug loading capacity and a good ability for controlled drug release. The pH-dependent release behaviour of MTX from MTX@gelatin-GNS showed that the release amount under acid conditions was much higher than that under neutral conditions, indicating a gelatin-mediated sustained release process.

引用

页码：1532 / 1537

页数：6

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