Aspirin, salicylates, and cancer

被引：234
作者：
Elwood, Peter C. [2 ]
Gallagher, Alison M. [1 ]
Duthie, Garry G. [3 ]
Mur, Luis A. J. [4 ]
Morgan, Gareth [5 ]
机构：
[1] Univ Ulster, No Ireland Ctr Food & Hlth, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland
[2] Cardiff Univ, Sch Med, Cardiff, Wales
[3] Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen, Scotland
[4] Univ Wales, Inst Biol Sci, Aberystwyth, Dyfed, Wales
[5] Welsh Aspirin Grp, Swansea, W Glam, Wales
来源：
LANCET | 2009年 / 373卷 / 9671期
关键词：
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOW-DOSE ASPIRIN; COLORECTAL-CANCER; BREAST-CANCER; INDUCE APOPTOSIS; RANDOMIZED-TRIAL; COLON-CANCER; GENOMIC INSTABILITY; MEDIATED APOPTOSIS; PRIMARY PREVENTION;
D O I：
10.1016/S0140-6736(09)60243-9
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and randomisation would be ethically unacceptable because vascular protection would have to be denied to a proportion of the participants. However, opportunistic trials of aspirin, designed to test vascular protection, provide some evidence of a reduction in cancer, but only after at least 10 years. We summarise evidence for the potential benefit of aspirin and natural salicylates in cancer prevention. Possible mechanisms of action and directions for further work are discussed, and implications for clinical practice are considered.
引用
收藏
页码：1301 / 1309
页数：9
相关论文
共 117 条
  • [41] Colorectal cancer chemoprevention - An overview of the science
    Hawk, ET
    Umar, A
    Viner, JL
    [J]. GASTROENTEROLOGY, 2004, 126 (05) : 1423 - 1447
  • [42] Aspirin and risk of hemorrhagic stroke - A meta-analysis of randomized controlled trials
    He, J
    Whelton, PK
    Vu, B
    Klag, MJ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 280 (22): : 1930 - 1935
  • [43] Incidence of serious upper gastrointestinal bleeding/perforation in the general population:: Review of epidemiologic studies
    Hernández-Díaz, S
    Rodríguez, LAG
    [J]. JOURNAL OF CLINICAL EPIDEMIOLOGY, 2002, 55 (02) : 157 - 163
  • [44] Prostaglandin synthase 2
    Herschman, HR
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM, 1996, 1299 (01): : 125 - 140
  • [45] Recent advances in chemoprevention of cancer
    Hong, WK
    Sporn, MB
    [J]. SCIENCE, 1997, 278 (5340) : 1073 - 1077
  • [46] *INT AG RES CANC, 1997, IARC HDB CANC PREV N, V1
  • [47] IWAMA T, 1994, CANCER, V73, P2065, DOI 10.1002/1097-0142(19940415)73:8<2065::AID-CNCR2820730809>3.0.CO
  • [48] 2-O
  • [49] Low-dose aspirin and vitamin E - Challenges and opportunities in cancer prevention
    Jacobs, EJ
    Thun, MJ
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2005, 294 (01): : 105 - 106
  • [50] A large cohort study of aspirin and other nonsteroidal anti-inflammatory drugs and prostate cancer incidence
    Jacobs, EJ
    Rodriguez, C
    Mondul, AM
    Connell, CJ
    Henley, SJ
    Calle, EE
    Thun, MJ
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2005, 97 (13): : 975 - 980
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