Aspirin, salicylates, and cancer

被引：237

作者：

Elwood, Peter C. ^{[2
]}

Gallagher, Alison M. ^{[1
]}

Duthie, Garry G. ^{[3
]}

Mur, Luis A. J. ^{[4
]}

Morgan, Gareth ^{[5
]}

机构：

[1] Univ Ulster, No Ireland Ctr Food & Hlth, Sch Biomed Sci, Coleraine BT52 1SA, Londonderry, North Ireland

[2] Cardiff Univ, Sch Med, Cardiff, Wales

[3] Univ Aberdeen, Rowett Inst Nutr & Hlth, Aberdeen, Scotland

[4] Univ Wales, Inst Biol Sci, Aberystwyth, Dyfed, Wales

[5] Welsh Aspirin Grp, Swansea, W Glam, Wales

来源：

LANCET | 2009年 / 373卷 / 9671期

关键词：

NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LOW-DOSE ASPIRIN; COLORECTAL-CANCER; BREAST-CANCER; INDUCE APOPTOSIS; RANDOMIZED-TRIAL; COLON-CANCER; GENOMIC INSTABILITY; MEDIATED APOPTOSIS; PRIMARY PREVENTION;

D O I：

10.1016/S0140-6736(09)60243-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Evidence from a wide range of sources suggests that individuals taking aspirin and related non-steroidal anti-inflammatory drugs have reduced risk of large bowel cancer. Work in animals supports cancer reduction with aspirin, but no long-term randomised clinical trials exist in human beings, and randomisation would be ethically unacceptable because vascular protection would have to be denied to a proportion of the participants. However, opportunistic trials of aspirin, designed to test vascular protection, provide some evidence of a reduction in cancer, but only after at least 10 years. We summarise evidence for the potential benefit of aspirin and natural salicylates in cancer prevention. Possible mechanisms of action and directions for further work are discussed, and implications for clinical practice are considered.

引用

页码：1301 / 1309

页数：9

共 117 条

[1] NSAIDs and breast cancer: a possible prevention and treatment strategy [J].

Agrawal, A. ;

Fentiman, I. S. .

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2008, 62 (03) :444-449

[2] Nonsteroidal anti-inflammatory drugs and aspirin for the prevention of colorectal adenomas and cancer: A systematic review [J].

Asano, TK ;

McLeod, RS .

DISEASES OF THE COLON & RECTUM, 2004, 47 (05) :665-673

[3] Chemoprevention of spontaneous intestinal adenomas in the adenomatous polyposis coli Min mouse model with aspirin [J].

Barnes, CJ ;

Lee, M .

GASTROENTEROLOGY, 1998, 114 (05) :873-877

[4]

Baron JA, 2003, PROG EXP TUMOR RES, V37, P1

[5] A randomized trial of aspirin to prevent colorectal adenomas [J].

Baron, JA ;

Cole, BF ;

Sandler, RS ;

Haile, RW ;

Ahnen, D ;

Bresalier, R ;

McKeown-Eyssen, G ;

Summers, RW ;

Rothstein, R ;

Burke, CA ;

Snover, DC ;

Church, TR ;

Allen, JI ;

Beach, M ;

Beck, GJ ;

Bond, JH ;

Byers, T ;

Greenberg, ER ;

Mandel, JS ;

Marcon, N ;

Mott, LA ;

Pearson, L ;

Saibil, F ;

van Stolk, RU .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (10) :891-899

[6] Oxidative stress is responsible for mitochondrial permeability transition induction by salicylate in liver mitochondria [J].

Battaglia, V ;

Salvi, M ;

Toninello, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (40) :33864-33872

[7] Salicylic acid in soups prepared from organically and non-organically grown vegetables [J].

Baxter, GJ ;

Graham, AB ;

Lawrence, JR ;

Wiles, D ;

Paterson, JR .

EUROPEAN JOURNAL OF NUTRITION, 2001, 40 (06) :289-292

[8] Aspirin and salicylate induce apoptosis and activation of caspases in B-cell chronic lymphocytic leukemia cells [J].

Bellosillo, B ;

Piqué, M ;

Barragán, M ;

Castaño, E ;

Villamor, N ;

Colomer, D ;

Montserrat, E ;

Pons, G ;

Gil, J .

BLOOD, 1998, 92 (04) :1406-1414

[9]

BENNETT A, 1975, GUT, V16, P409

[10] Salicylic acid in the serum of subjects not taking aspirin. Comparison of salicylic acid concentrations in the serum of vegetarians, non-vegetarians, and patients taking low dose aspirin [J].

Blacklock, CJ ;

Lawrence, JR ;

Wiles, D ;

Malcolm, EA ;

Gibson, IH ;

Kelly, CJ ;

Paterson, JR .

JOURNAL OF CLINICAL PATHOLOGY, 2001, 54 (07) :553-555

← 1 2 3 4 5 6 7 8 9 10 →