Malignant Rhabdoid Tumor of the Spine in an Infant: Case Report and Review of the Literature

被引：12

作者：

Fridley, Jared S. ^{[1
]}

Chamoun, Roukoz B. ^{[1
]}

Whitehead, William E. ^{[1
]}

Curry, Daniel J. ^{[1
]}

Luerssen, Thomas G. ^{[1
]}

Adesina, Adekunle ^{[2
]}

Jea, Andrew ^{[1
]}

机构：

[1] Texas Childrens Hosp, Baylor Coll Med, Dept Neurosurg, Div Pediat Neurosurg,Neurospine Ctr, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Baylor Coll Med, Dept Pathol, Houston, TX 77030 USA

来源：

PEDIATRIC NEUROSURGERY | 2009年 / 45卷 / 03期

关键词：

Cervical spine; Malignant rhabdoid tumor; Pediatric spine; Spine; ATYPICAL TERATOID/RHABDOID TUMOR; CENTRAL-NERVOUS-SYSTEM; NATIONAL-WILMS-TUMOR; PATHOLOGICAL FEATURES; DEFINITION; KIDNEY; ENTITY; BRAIN;

D O I：

10.1159/000224622

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Malignant rhabdoid tumors of the spine are rare pediatric neoplasms that have a poor prognosis. The histological, ultrastructural, and immunohistochemical features are essential elements used in their diagnosis. We report the case of a malignant rhabdoid tumor of the cervical spine in a 13-month-old infant. Tumor cells were vimentin positive with prominent nucleoli indented by eosinophilic cytoplasmic inclusions containing intermediate filaments. INI1 immunostaining was negative. This patient was operated on twice for symptomatic spinal cord compression. Despite chemotherapy, she developed worsening leptomeningeal dissemination, lower cranial nerve dysfunction, and hydrocephalus that did not respond to CSF diversion. She died 4 months after initial diagnosis. We review the literature on spinal malignant rhabdoid tumor and discuss the nomenclature, pathology, radiology, treatment, and outcomes of this rare entity. Copyright (C) 2009 S. Karger AG, Basel

引用

页码：237 / 243

页数：7

共 31 条

[1] Atypical teratoid/rhabdoid tumors of the central nervous system: Clinical, radiographic and pathologic features [J].