Mitochondrial transplantation: applications for pediatric patients with congenital heart disease

被引：75

作者：

Emani, Sitaram M. ^{[1
]}

McCully, James D. ^{[1
]}

机构：

[1] Boston Childrens Hosp, Dept Cardiovasc Surg, Boston, MA USA

来源：

TRANSLATIONAL PEDIATRICS | 2018年 / 7卷 / 02期

关键词：

Mitochondria; extracorporeal membrane oxygenation (ECMO); ISCHEMIA-REPERFUSION INJURY; ACUTE MYOCARDIAL-INFARCTION; GENDER-RELATED DIFFERENCES; RABBIT HEART; CARDIOPROTECTION; CALCIUM; TRIAL; ISCHEMIA/REPERFUSION; RESPIRATION; INHIBITION;

D O I：

10.21037/tp.2018.02.02

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Mitochondrial transplantation refers to transplantation of respiratory competent mitochondria from healthy tissue into tissues injured by ischemia and reperfusion. This technique has been utilized for recovery of myocardial dysfunction in pediatric patients. The preclinical experience and initial patient experience with this technique are reviewed in this article. Initial experience is with pediatric patients undergoing extracorporeal membrane oxygenation support following myocardial ischemia and reperfusion. The initial pediatric experience suggests low side effect profile with favorable efficacy in a small group of patients.

引用

页码：169 / 175

页数：7

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