Treatment of esophageal carcinoma

被引:45
作者
Lerut, T [1 ]
Coosemans, W [1 ]
De Leyn, P [1 ]
Van Raemdonck, D [1 ]
Deneffe, G [1 ]
Decker, G [1 ]
机构
[1] Univ Hosp Gasthuisberg, Dept Thorac Surg, B-3000 Louvain, Belgium
关键词
D O I
10.1378/chest.116.suppl_3.463S
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Cancel of the esophagus and gastroesophageal junction remains a virulent malignancy with an overall poor prognosis. Especially in the Western hemisphere, the incidence of adenocarcinoma is sharply rising. Over the last two decades, surgery has become the mainstay of treatment. Decreased surgical mortality and standardization of oncologic principles focusing on the completeness of resection are believed to be responsible for the improved 5-year survival rates, which are reaching greater than or equal to 30%. Until now, there has been no proven benefit from combined neoadjuvant treatment modalities using chemotherapy or chemoradiotherapy except for the subset of patients showing a complete response at pathologic examination. Further research should focus on new chemotherapeutic agents and the development of molecular markers that allow better identification of candidates for multimodality regimens.
引用
收藏
页码:463S / 465S
页数:3
相关论文
共 43 条
[1]   PRINCIPLES OF SURGICAL-TREATMENT FOR CARCINOMA OF THE ESOPHAGUS - ANALYSIS OF LYMPH-NODE INVOLVEMENT [J].
AKIYAMA, H ;
TSURUMARU, M ;
KAWAMURA, T ;
ONO, Y .
ANNALS OF SURGERY, 1981, 194 (04) :438-446
[2]  
ALSARRAF M, 1993, P AN M AM SOC CLIN, V12, P197
[3]   En bloc esophagectomy improves survival for stage III esophageal cancer [J].
Altorki, NK ;
Girardi, L ;
Skinner, DB .
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 1997, 114 (06) :948-955
[4]  
BLOT WJ, 1994, SEMIN ONCOL, V21, P403
[5]   Chemoradiotherapy followed by surgery compared with surgery alone in squamous-cell cancer of the esophagus [J].
Bosset, JF ;
Gignoux, M ;
Triboulet, JP ;
Tiret, E ;
Mantion, G ;
Elias, D ;
Lozach, P ;
Ollier, JC ;
Pavy, JJ ;
Mercier, M ;
Sahmoud, T .
NEW ENGLAND JOURNAL OF MEDICINE, 1997, 337 (03) :161-167
[6]   p53 alterations in oesophageal cancer: association with clinicopathological features, risk factors, and survival [J].
Casson, AG ;
Tammemagi, M ;
Eskandarian, S ;
Redston, M ;
McLaughlin, J ;
Ozcelik, H .
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY, 1998, 51 (02) :71-79
[7]   ESOPHAGEAL SQUAMOUS-CELL CARCINOMA .2. A CRITICAL-REVIEW OF RADIOTHERAPY [J].
EARLAM, R ;
CUNHAMELO, JR .
BRITISH JOURNAL OF SURGERY, 1980, 67 (07) :457-461
[8]   ESOPHAGEAL SQUAMOUS-CELL CARCINOMA .1. A CRITICAL-REVIEW OF SURGERY [J].
EARLAM, R ;
CUNHAMELO, JR .
BRITISH JOURNAL OF SURGERY, 1980, 67 (06) :381-390
[9]   PREOPERATIVE CHEMORADIATION FOLLOWED BY TRANSHIATAL ESOPHAGECTOMY FOR CARCINOMA OF THE ESOPHAGUS - FINAL REPORT [J].
FORASTIERE, AA ;
ORRINGER, MB ;
PEREZTAMAYO, C ;
URBA, SG ;
ZAHURAK, M .
JOURNAL OF CLINICAL ONCOLOGY, 1993, 11 (06) :1118-1123
[10]   THE VALUE OF PREOPERATIVE RADIOTHERAPY IN ESOPHAGEAL CANCER - RESULTS OF A STUDY OF THE EORTC [J].
GIGNOUX, M ;
ROUSSEL, A ;
PAILLOT, B ;
GILLET, M ;
SCHLAG, P ;
FAVRE, JP ;
DALESIO, O ;
BUYSE, M ;
DUEZ, N .
WORLD JOURNAL OF SURGERY, 1987, 11 (04) :426-432