Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients

被引:25
作者
Bernabeu-Wittel, Maximo [1 ]
Gonzalez-Molina, Alvaro [1 ]
Fernandez-Ojeda, Rocio [2 ]
Diez-Manglano, Jesus [3 ]
Salgado, Fernando [4 ]
Soto-Martin, Maria [5 ]
Muniesa, Marta [6 ]
Ollero-Baturone, Manuel [1 ]
Gomez-Salgado, Juan [7 ,8 ]
机构
[1] Hosp Univ Virgen Rocio, Internal Med Dept, Seville 41013, Spain
[2] Hosp San Juan de Dios Aljarafe, Seville 41930, Spain
[3] Hosp Royo Villanova, Zaragoza 50015, Spain
[4] Hosp Reg, Malaga 29010, Spain
[5] Hosp Juan Ramon Jimenez, Huelva 21005, Spain
[6] Hosp San Juan de Dios Pamplona, Pamplona 31006, Spain
[7] Univ Huelva, Dept Sociol Social Work & Publ Hlth, Huelva 21071, Spain
[8] Univ Espiritu Santo, Safety & Hlth Posgrad Program, Guayaquil 091650, Ecuador
来源
JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 04期
关键词
polypathological patients; multimorbidity; sarcopenia; frailty; PREVALENCE; INTERVENTIONS; POPULATION; DEFINITION; CONSENSUS; CRITERIA; ADULTS; SCALE;
D O I
10.3390/jcm8040535
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prevalence, relationships and outcomes of sarcopenia and frailty in polypathological patients remain unknown. We performed a multicenter prospective observational study in six hospitals in order to assess prevalence, clinical features, outcome and associated risk factors of sarcopenia and frailty in a hospital-based population of polypathological patients. The cohort was recruited by performing prevalence surveys every 14 days during the inclusion period (March 2012-June 2016). Sarcopenia was assessed by means of EWGSOP criteria and frailty by means of Fried's criteria. Skeletal muscle mass was measured by tetrapolar bioimpedanciometry. All patients were followed for 12 months. Factors associated with sarcopenia, frailty and mortality were analyzed by multivariate logistic regression, and Kaplan-Meier curves. A total of 444 patients (77.3 +/- 8.4 years, 55% males) were included. Sarcopenia was present in 97 patients (21.8%), this being moderate in 54 (12.2%), and severe in 43 (9.6%); frailty was present in 278 patients (62.6%), and 140 (31.6%) were pre-frail; combined sarcopenia and frailty were present in the same patient in 80 (18%) patients. Factors independently associated to the presence of both, sarcopenia and frailty were female gender, older age, different chronic conditions, poor functional status, low body mass index, asthenia and depressive disorders, and low leucocytes and lymphocytes count. Mortality in the 12-months follow-up period was 40%. Patients with sarcopenia, frailty or both survived significantly less than those without these conditions. Sarcopenia and frailty are frequent and interrelated conditions in polypathological patients, shadowing their survival. Their early recognition and management could improve health-related outcomes in this population.
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页数:13
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