Impact of Sarcopenia and Frailty in a Multicenter Cohort of Polypathological Patients

被引:25
作者
Bernabeu-Wittel, Maximo [1 ]
Gonzalez-Molina, Alvaro [1 ]
Fernandez-Ojeda, Rocio [2 ]
Diez-Manglano, Jesus [3 ]
Salgado, Fernando [4 ]
Soto-Martin, Maria [5 ]
Muniesa, Marta [6 ]
Ollero-Baturone, Manuel [1 ]
Gomez-Salgado, Juan [7 ,8 ]
机构
[1] Hosp Univ Virgen Rocio, Internal Med Dept, Seville 41013, Spain
[2] Hosp San Juan de Dios Aljarafe, Seville 41930, Spain
[3] Hosp Royo Villanova, Zaragoza 50015, Spain
[4] Hosp Reg, Malaga 29010, Spain
[5] Hosp Juan Ramon Jimenez, Huelva 21005, Spain
[6] Hosp San Juan de Dios Pamplona, Pamplona 31006, Spain
[7] Univ Huelva, Dept Sociol Social Work & Publ Hlth, Huelva 21071, Spain
[8] Univ Espiritu Santo, Safety & Hlth Posgrad Program, Guayaquil 091650, Ecuador
来源
JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 04期
关键词
polypathological patients; multimorbidity; sarcopenia; frailty; PREVALENCE; INTERVENTIONS; POPULATION; DEFINITION; CONSENSUS; CRITERIA; ADULTS; SCALE;
D O I
10.3390/jcm8040535
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The prevalence, relationships and outcomes of sarcopenia and frailty in polypathological patients remain unknown. We performed a multicenter prospective observational study in six hospitals in order to assess prevalence, clinical features, outcome and associated risk factors of sarcopenia and frailty in a hospital-based population of polypathological patients. The cohort was recruited by performing prevalence surveys every 14 days during the inclusion period (March 2012-June 2016). Sarcopenia was assessed by means of EWGSOP criteria and frailty by means of Fried's criteria. Skeletal muscle mass was measured by tetrapolar bioimpedanciometry. All patients were followed for 12 months. Factors associated with sarcopenia, frailty and mortality were analyzed by multivariate logistic regression, and Kaplan-Meier curves. A total of 444 patients (77.3 +/- 8.4 years, 55% males) were included. Sarcopenia was present in 97 patients (21.8%), this being moderate in 54 (12.2%), and severe in 43 (9.6%); frailty was present in 278 patients (62.6%), and 140 (31.6%) were pre-frail; combined sarcopenia and frailty were present in the same patient in 80 (18%) patients. Factors independently associated to the presence of both, sarcopenia and frailty were female gender, older age, different chronic conditions, poor functional status, low body mass index, asthenia and depressive disorders, and low leucocytes and lymphocytes count. Mortality in the 12-months follow-up period was 40%. Patients with sarcopenia, frailty or both survived significantly less than those without these conditions. Sarcopenia and frailty are frequent and interrelated conditions in polypathological patients, shadowing their survival. Their early recognition and management could improve health-related outcomes in this population.
引用
收藏
页数:13
相关论文
共 47 条
  • [1] [Anonymous], POP STRUCT AG
  • [2] Bioelectrical impedance analysis in clinical practice: a new perspective on its use beyond body composition equations
    Barbosa-Silva, MCG
    Barros, AJD
    [J]. CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE, 2005, 8 (03) : 311 - 317
  • [3] A multi-institutional, hospital-based assessment of clinical, functional, sociofamilial and health-care characteristics of polypathological patients (PP)
    Bernabeu-Wittel, M.
    Baron-Franco, B.
    Murcia-Zaragoza, J.
    Fuertes-Martin, A.
    Ramos-Cantos, C.
    Fernandez-Moyano, A.
    Galindo, F. J.
    Ollero-Baturone, M.
    [J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2011, 53 (03) : 284 - 291
  • [4] Development of a new predictive model for polypathological patients. The PROFUND index
    Bernabeu-Wittel, M.
    Ollero-Baturone, M.
    Moreno-Gavino, L.
    Baron-Franco, B.
    Fuertes, A.
    Murcia-Zaragoza, J.
    Ramos-Cantos, C.
    Aleman, A.
    Fernandez-Moyano, A.
    [J]. EUROPEAN JOURNAL OF INTERNAL MEDICINE, 2011, 22 (03) : 311 - 317
  • [5] Peeking through the cracks: An assessment of the prevalence, clinical characteristics and health-related quality of life (HRQoL) of people with polypathology in a hospital setting
    Bernabeu-Wittel, M.
    Jadad, A.
    Moreno-Gavino, L.
    Hernandez-Quiles, C.
    Toscano, F.
    Cassani, M.
    Ramirez, N.
    Ollero-Baturone, M.
    [J]. ARCHIVES OF GERONTOLOGY AND GERIATRICS, 2010, 51 (02) : 185 - 191
  • [6] Functional Decline Over 1-year Follow-up in a Multicenter Cohort of Polypathological Patients: A New Approach to Functional Prognostication
    Bernabeu-Wittelt, Maximo
    Ero-Baturone, Manuel
    Ruiz-Cantero, Alberto
    Moreno-Gavino, Lourdes
    Baron-Franco, Bosco
    Fuertes, Aurelio
    Murcia-Zaragoza, Jose
    Ramos-Cantos, Carmen
    Aleman, Antonio
    [J]. INTERNATIONAL JOURNAL OF GERONTOLOGY, 2012, 6 (02) : 68 - 74
  • [7] Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease
    Bestall, JC
    Paul, EA
    Garrod, R
    Garnham, R
    Jones, PW
    Wedzicha, JA
    [J]. THORAX, 1999, 54 (07) : 581 - 586
  • [8] Buckinx F, 2017, J MUSCULOSKEL NEURON, V17, P209
  • [9] Frailty and Primary Sarcopenia: A Review
    Carmeli, Eli
    [J]. CLINICAL RESEARCH AND PRACTICE, 2017, 1020 : 53 - 68
  • [10] Overlaps between Frailty and Sarcopenia Definitions
    Cederholm, Tommy
    [J]. FRAILTY: PATHOPHYSIOLOGY, PHENOTYPE AND PATIENT CARE, 2015, 83 : 65 - 69