Blockade of ICAM-1: A novel way of vasculitis treatment

被引：11
作者：
Xu, Youhua [1 ]
Li, Shengnan [1 ]
机构：
[1] Nanjing Med Univ, Dept Pharmacol, Nanjing 210029, Peoples R China
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2009年 / 381卷 / 04期
关键词：
Vasculitis; Intercellular adhesion molecule-1; Inflammation; Therapy; INTERCELLULAR-ADHESION MOLECULE-1; INFLAMMATORY-BOWEL-DISEASE; TUMOR-NECROSIS-FACTOR; SYSTEMIC VASCULITIS; ENDOTHELIAL-CELLS; E-SELECTIN; TNF-ALPHA; EXPRESSION; ATHEROSCLEROSIS; VCAM-1;
D O I：
10.1016/j.bbrc.2009.02.111
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vasculitis is becoming more common worldwide, but there is no effective therapeutic method towards this series of disease till now. Intercellular adhesion molecule (ICAM)-1 is one of an important cell adhesion molecules (CAMs) family glycoprotein that plays pivotal role in inflammation process and participates in vasculitis. Blockade of ICAM-1 has been witnessed with its satisfactory effect on inflammatory disease treatment. Therefore, this method may be considered as a novel way towards treatment of vasculitis. (C) 2009 Published by Elsevier Inc.
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收藏
页码：459 / 461
页数：3
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