Background: We evaluated the role of Gamma Knife SRS in the multidisciplinary management of metastatic cancer to the pituitary gland. Methods: We retrospectively reviewed records of 18 consecutive pituitary metastasis patients who underwent Gamma Knife SRS during a 21-year experience. The median patient age was 57.6 years (range, 27.0-81.1 years). There were 5 patients who had initial surgical resection of their pituitary metastasis, 5 who had fractionated radiation, and 7 who had CT before SRS. The median radiosurgery target volume was 3.5 mL (range, 0.2-18.0 mL), and the median marginal dose was 13.0 Gy (range, 9-18 Gy). Results: The overall survival after SRS at 3, 6, and 12 months, respectively, was 66%, 36%, and 18%. The median survival after SRS was 5.2 months. The progression-free survival after SRS was 100% and 66.7% at 6 and 12 months, respectively. The only factor associated with an improved overall survival was younger age at presentation. Diabetes insipidus improved in 3 (42.9%) of 7 patients. Neurological symptoms or signs improved in 4 (50.0%) of 8 patients. Three (16.7%) patients developed new neurological deficits due to tumor progression despite SRS. Conclusion: Development of a pituitary metastasis is an ominous finding in the context of systemic cancer. Stereotactic radiosurgery is an effective palliative approach for most patients with pituitary metastasis. (C) 2009 Elsevier Inc. All rights reserved.
机构:
Hofstra Northwell, Donald & Barbara Zucker Sch Med, Dept Neurosurg, Manhasset, NY 11549 USAHofstra Northwell, Donald & Barbara Zucker Sch Med, Dept Neurosurg, Manhasset, NY 11549 USA
Begley, Sabrina L.
Goenka, Anuj
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Hofstra Northwell, Donald & Barbara Zucker Sch Med, Dept Radiat Med, Lake Success, NY USAHofstra Northwell, Donald & Barbara Zucker Sch Med, Dept Neurosurg, Manhasset, NY 11549 USA
Goenka, Anuj
Schulder, Michael
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Hofstra Northwell, Donald & Barbara Zucker Sch Med, Dept Neurosurg, Manhasset, NY 11549 USAHofstra Northwell, Donald & Barbara Zucker Sch Med, Dept Neurosurg, Manhasset, NY 11549 USA
机构:
Natl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Lin, Chun-Shu
Selch, Michael T.
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Selch, Michael T.
Lee, Steve P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Lee, Steve P.
Wu, Jeffrey K.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Wu, Jeffrey K.
Xiao, Furen
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Xiao, Furen
Hong, David S.
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h-index: 0
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Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Hong, David S.
Chen, Chien-Hua
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h-index: 0
机构:
Taichung Vet Gen Hosp, Dept Neurosurg, Taichung, TaiwanNatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Chen, Chien-Hua
Hussain, Aamir
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Hussain, Aamir
Lee, Percy P.
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Radiat Oncol, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
Lee, Percy P.
De Salles, Antonio A.
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h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurosurg, Los Angeles, CA 90095 USANatl Def Med Ctr, Dept Radiat Oncol, Triserv Gen Hosp, Taipei 114, Taiwan
机构:
Brown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Tufts Med Ctr, Dept Radiat Oncol, Boston, MA USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Koffer, Paul
Chan, Jason
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机构:
Brown Univ, Warren Alpert Med Sch, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Chan, Jason
Rava, Paul
论文数: 0引用数: 0
h-index: 0
机构:
UMass Mem Med Ctr, Dept Radiat Oncol, Worcester, MA USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Rava, Paul
Gorovets, Daniel
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h-index: 0
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Brown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Tufts Med Ctr, Dept Radiat Oncol, Boston, MA USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Gorovets, Daniel
Ebner, Daniel
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h-index: 0
机构:
Brown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Ebner, Daniel
Savir, Guy
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Tufts Med Ctr, Dept Radiat Oncol, Boston, MA USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Savir, Guy
Kinsella, Timothy
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Kinsella, Timothy
Cielo, Deus
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h-index: 0
机构:
Brown Univ, Warren Alpert Med Sch, Dept Neurosurg, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
Cielo, Deus
Hepel, Jaroslaw T.
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机构:
Brown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USABrown Univ, Warren Alpert Med Sch, Dept Radiat Oncol, Providence, RI 02912 USA
机构:
Dana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USADana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Kelly, Paul J.
Lin, Nancy U.
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h-index: 0
机构:
Harvard Univ, Sch Med, Boston, MA USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USADana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Lin, Nancy U.
Claus, Elizabeth B.
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h-index: 0
机构:
Harvard Univ, Sch Med, Boston, MA USA
Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA
Yale Univ, Sch Med, New Haven, CT USADana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Claus, Elizabeth B.
Quant, Eudocia C.
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机构:
Harvard Univ, Sch Med, Boston, MA USA
Dana Farber Brigham & Womens Ctr, Dept Neurol, Boston, MA USADana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Quant, Eudocia C.
Weiss, Stephanie E.
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机构:
Dana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USADana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Weiss, Stephanie E.
Alexander, Brian M.
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机构:
Dana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USADana Farber Brigham & Womens Canc Ctr, Dept Radiat Oncol, Boston, MA USA