Association of COMT Val158Met Polymorphism with Psychopathological Symptoms in Patients with Eating Disorders

被引:8
|
作者
Gervasini, G. [1 ]
Gonzalez, L. M. [1 ]
Mota-Zamorano, S. [1 ]
Gamero-Villarroel, C. [1 ]
Carrillo, J. A. [1 ]
Flores, I. [2 ]
Garcia-Herraiz, A. [2 ]
机构
[1] Univ Extremadura, Med Sch, Dept Med & Surg Therapeut, Avda Elvas S-N, E-06005 Badajoz, Spain
[2] Inst Mental Disorders Extremadura, Eating Disorders Unit, Badajoz, Spain
关键词
Eating disorders; Anorexia Nervosa; Bulimia Nervosa; dopamine; COMT; polymorphism; binge-eating; O-METHYLTRANSFERASE COMT; ANOREXIA-NERVOSA; BULIMIA-NERVOSA; FUNCTIONAL POLYMORPHISM; DOPAMINE; GENE; METAANALYSIS; PERSONALITY; GENOTYPE; CORTEX;
D O I
10.2174/1566524018666180608090512
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Background: Dopamine physiological functions make dopaminergic genes suitable candidates for association studies in eating disorders (ED). A Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene, which is involved in dopamine degradation, has been studied in relation to ED. Objective: We aimed to analyze the association between this polymorphism and general psychopathological symptoms that are often coupled to these disorders. Method: A total of 303 ED patients, diagnosed according to DSM-5 criteria, completed the SCL-90R questionnaire and were genotyped for the Val158Met polymorphism. Results: There were significant differences in the global indices of the SCL-90R inventory between the three ED groups (Anorexia Nervosa (AN), Bulimia Nervosa (BN) and binge-eating disorder; ANOVA-p < 0.05). Females with BN showed the highest scores (worse symptomatology) of all participants. In this group, a gene-dose effect was observed on the psychometric evaluation of the patients, as Val/Val carriers displayed the highest scores for all the SCL-90R scales, followed by Val/Met and then Met/Met carriers. Significant differences between genotypes were observed in the Obsessive-Compulsive (p = 0.018), Paranoid Ideation (p = 0.0005) and Psychoticism (p = 0.039) scales, as well as in the PSDI (p = 0.014) general index. Conclusion: The results taken together suggest that COMT genetic variability may contribute to general psychopathological symptoms in patients with BN.
引用
收藏
页码:65 / 70
页数:6
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