Plasma membrane content of insulin-regulated glucose transporter in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a model of non-insulin-dependent diabetes mellitus

被引：25
|
作者：
Sato, T
Man, ZW
Toide, K
Asahi, Y
机构：
[1] Third Tokushima Inst. New Drug Res., Otsuka Pharmaceutical Co., L.
来源：
FEBS LETTERS | 1997年 / 407卷 / 03期
关键词：
Otsuka Long-Evans Tokushima fatty rat; insulin-regulated glucose transporter; skeletal muscle; noninsulin-dependent diabetes mellitus model; INDUCED TRANSLOCATION; RESISTANCE; EXPRESSION; GLUT-4; NIDDM;
D O I：
10.1016/S0014-5793(97)00369-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The male Otsuka Long-Evans Tokushima Fatty (OLETF) rat shows insulin resistance in skeletal muscle and visceral obesity. To obtain information on the mechanism of the insulin resistance in the diabetic rats, we examined the content of insulin-regulated glucose transporter (GLUT4) in skeletal muscles. The results indicate that the total content of the transporter is significantly decreased (P < 0.05) in muscles of the diabetic rats. Plasma membrane content of the GLUT4 protein in muscles of the diabetic rats was increased in the basal state as compared to control rats. Hyperinsulinemic clamps increased GLUT4 levels in the plasma membrane of control rats but failed to do so in the diabetic rats. The distribution of GLUT4 in OLETF rat is reminiscent of the characteristics of human non-insulin-dependent diabetes mellitus. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：329 / 332
页数：4
相关论文
共 19 条
  • [1] Glucose transporter levels in a male spontaneous non-insulin-dependent diabetes mellitus rat of the Otsuka Long-Evans Tokushima Fatty strain
    Toide, K
    Man, ZW
    Asahi, Y
    Sato, T
    Nakayama, N
    Noma, Y
    Oka, Y
    Shima, K
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1997, 38 (03) : 151 - 160
  • [2] Identification of epistatic interactions involved in non-insulin-dependent diabetes mellitus in the Otsuka Long-Evans Tokushima Fatty rat
    Yamada, T
    Miyake, T
    Sugiura, K
    Narita, A
    Wei, K
    Wei, SW
    Moralejo, DH
    Ogino, T
    Gaillard, C
    Sasaki, Y
    Matsumoto, K
    EXPERIMENTAL ANIMALS, 2001, 50 (02) : 115 - 123
  • [3] INSULIN-RESISTANCE IN SKELETAL-MUSCLE OF THE MALE OTSUKA LONG-EVANS TOKUSHIMA FATTY RAT, A NEW MODEL OF NIDDM
    SATO, T
    ASAHI, Y
    TOIDE, K
    NAKAYAMA, N
    DIABETOLOGIA, 1995, 38 (09) : 1033 - 1041
  • [4] Cilnidipine Improves Insulin Sensitivity in the Otsuka Long-Evans Tokushima Fatty Rat, a Model of Spontaneous NIDDM
    Nagakatsu Harada
    Masaharu Onaka
    Sadaichi Sakamoto
    Yasuharu Niwa
    Yutaka Nakaya
    Cardiovascular Drugs and Therapy, 1999, 13 : 519 - 523
  • [5] Cilnidipine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM
    Harada, N
    Onaka, M
    Sakamoto, S
    Niwa, Y
    Nakaya, Y
    CARDIOVASCULAR DRUGS AND THERAPY, 1999, 13 (06) : 519 - 523
  • [6] Centrally administered TRH-induced insulin secretion is impaired in the Otsuka-Long-Evans-Tokushima Fatty rats, a model of spontaneous non-insulin-dependent diabetes mellitus
    Chen, Y
    Uemura, K
    Yoshioka, S
    Surina-Baumgartner, DM
    Miura, H
    Tamagawa, T
    Hotta, N
    Iguchi, A
    JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1998, 71 (01): : 10 - 17
  • [7] Sildenafil, a phosphodiesterase type 5 inhibitor, attenuates diabetic nephropathy in non-insulin-dependent Otsuka Long-Evans Tokushima Fatty rats
    Kuno, Yoshihiro
    Iyoda, Masayuki
    Shibata, Takanori
    Hirai, Yuki
    Akizawa, Tadao
    BRITISH JOURNAL OF PHARMACOLOGY, 2011, 162 (06) : 1389 - 1400
  • [8] Downregulation of the skeletal muscle pyruvate dehydrogenase complex in the Otsuka Long-Evans Tokushima Fatty rat both before and after the onset of diabetes mellitus
    Bajotto, G
    Murakami, T
    Nagasaki, M
    Tamura, T
    Tamura, N
    Harris, RA
    Shimomura, Y
    Sato, Y
    LIFE SCIENCES, 2004, 75 (17) : 2117 - 2130
  • [9] Daily physical activity enhances reactivity to insulin in skeletal muscle arterioles of hyperphagic Otsuka Long-Evans Tokushima Fatty rats
    Mikus, Catherine R.
    Rector, R. Scott
    Arce-Esquivel, Arturo A.
    Libla, Jessica L.
    Booth, Frank W.
    Ibdah, Jamal A.
    Laughlin, M. Harold
    Thyfault, John P.
    JOURNAL OF APPLIED PHYSIOLOGY, 2010, 109 (04) : 1203 - 1210
  • [10] EFFECTS OF DIFFERENCE IN AMOUNT OF EXERCISE TRAINING ON PREVENTION OF DIABETES-MELLITUS IN THE OTSUKA-LONG-EVANS-TOKUSHIMA FATTY RATS, A MODEL OF SPONTANEOUS NON-INSULIN-DEPENDENT DIABETES-MELLITUS
    SHIMA, K
    SHI, K
    MIZUNO, A
    SANO, T
    ISHIDA, K
    YOSHIMOTO, S
    DIABETES RESEARCH AND CLINICAL PRACTICE, 1994, 23 (03) : 147 - 154
12