Plasma membrane content of insulin-regulated glucose transporter in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a model of non-insulin-dependent diabetes mellitus

被引：25
作者：
Sato, T
Man, ZW
Toide, K
Asahi, Y
机构：
[1] Third Tokushima Inst. New Drug Res., Otsuka Pharmaceutical Co., L.
来源：
FEBS LETTERS | 1997年 / 407卷 / 03期
关键词：
Otsuka Long-Evans Tokushima fatty rat; insulin-regulated glucose transporter; skeletal muscle; noninsulin-dependent diabetes mellitus model; INDUCED TRANSLOCATION; RESISTANCE; EXPRESSION; GLUT-4; NIDDM;
D O I：
10.1016/S0014-5793(97)00369-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The male Otsuka Long-Evans Tokushima Fatty (OLETF) rat shows insulin resistance in skeletal muscle and visceral obesity. To obtain information on the mechanism of the insulin resistance in the diabetic rats, we examined the content of insulin-regulated glucose transporter (GLUT4) in skeletal muscles. The results indicate that the total content of the transporter is significantly decreased (P < 0.05) in muscles of the diabetic rats. Plasma membrane content of the GLUT4 protein in muscles of the diabetic rats was increased in the basal state as compared to control rats. Hyperinsulinemic clamps increased GLUT4 levels in the plasma membrane of control rats but failed to do so in the diabetic rats. The distribution of GLUT4 in OLETF rat is reminiscent of the characteristics of human non-insulin-dependent diabetes mellitus. (C) 1997 Federation of European Biochemical Societies.
引用
收藏
页码：329 / 332
页数：4
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