Effect of oxytocin pretreatment on cannabis outcomes in a brief motivational intervention

被引：28

作者：

Sherman, Brian J. ^{[1
]}

Baker, Nathaniel L. ^{[2
]}

McRae-Clark, Aimee L. ^{[1
]}

机构：

[1] Med Univ South Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Dept Publ Hlth Sci, Charleston, SC 29425 USA

来源：

PSYCHIATRY RESEARCH | 2017年 / 249卷

关键词：

Oxytocin; Cannabis; Treatment; USE DISORDER; DEPENDENT INDIVIDUALS; INCREASES TRUST; ADDICTION; STRESS;

D O I：

10.1016/j.psychres.2017.01.027

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Motivational enhancement therapy (MET) is efficacious in reducing cannabis use, yet benefits are generally short-lived. Oxytocin is a hypothalamic neuropeptide that promotes prosocial behaviors and plays a role in drug-related neuroadaptations; as such, oxytocin may enhance the effect of MET on cannabis outcomes. Cannabis dependent adults were randomized to receive MET plus oxytocin (n=8) or placebo (n=8). Participants receiving oxytocin showed reductions in amount of cannabis used daily and number of sessions per day. Participants receiving placebo did not evidence significant reductions. Powered clinical trials of oxytocin-enhanced MET for cannabis use disorder are warranted.

引用

页码：318 / 320

页数：3

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