Systematic Review and Meta-analysis: Resting-State Functional Magnetic Resonance Imaging Studies of Attention-Deficit/Hyperactivity Disorder

被引:101
作者
Cortese, Samuele [1 ,2 ,3 ]
Aoki, Yuta Y. [5 ,6 ]
Itahashi, Takashi [5 ]
Castellanos, F. Xavier [1 ,4 ]
Eickhoff, Simon B. [7 ,8 ]
机构
[1] NYU Langone, Hassenfeld Childrens Hosp, New York, NY 10016 USA
[2] Univ Southampton, Solent NHS Trust, Southampton, Hants, England
[3] Univ Nottingham, Nottingham, England
[4] Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
[5] Showa Univ, Tokyo, Japan
[6] Natl Ctr Child Hlth & Dev, Tokyo, Japan
[7] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Syst Neurosci, Dusseldorf, Germany
[8] Res Ctr Julich, Inst Neurosci & Med Brain & Behav INM 7, Julich, Germany
基金
日本学术振兴会;
关键词
ADHD; ALE; meta-analysis; neuroimaging; resting state; BRAIN NETWORKS; CONNECTIVITY; ADHD; CHILDREN; DEFICIT; AREAS; METHYLPHENIDATE; IMPAIRMENTS; DYSFUNCTION; MEDICATION;
D O I
10.1016/j.jaac.2020.08.014
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
Objective: To conduct a meta-analysis of resting-state functional magnetic resonance imaging (R-fMRI) studies in children and adolescents with attention-deficit/hyperactivity disorder (ADHD) and in adults with ADHD to assess spatial convergence of findings from available studies. Method: Based on a preregistered protocol in PROSPERO (CRD42019119553), a large set of databases were searched up to April 9, 2019, with no language or article type restrictions. Study authors were systematically contacted for additional unpublished information/data. Resting-state functional magnetic resonance imaging studies using seed-based connectivity (SBC) or any other method (non-SBC) reporting whole-brain results of group comparisons between participants with ADHD and typically developing controls were eligible. Voxelwise meta-analysis via activation likelihood estimation with cluster-level familywise error (voxel-level: p < .001; cluster-level: p < .05) was used. Results: Thirty studies (18 SBC and 12 non-SBC), comprising 1,978 participants (1,094 with ADHD; 884 controls) were retained. The meta-analysis focused on SBC studies found no significant spatial convergence of ADHD-related hyperconnectivity or hypoconnectivity across studies. This nonsignificant finding remained after integrating 12 non-SBC studies into the main analysis and in sensitivity analyses limited to studies including only children or only non-medication-naive patients. Conclusion: The lack of significant spatial convergence may be accounted for by heterogeneity in study participants, experimental procedures, and analytic flexibility as well as in ADHD pathophysiology. Alongside other neuroimaging meta-analyses in other psychiatric conditions, the present results should inform the conduct and publication of future neuroimaging studies of psychiatric disorders.
引用
收藏
页码:61 / 75
页数:15
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