Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer

被引:52
作者
Yan, Yunmeng [1 ,2 ]
Fu, Guangzhen [1 ,2 ]
Ye, Yafei [1 ,2 ]
Ming, Liang [1 ,2 ]
机构
[1] Zhengzhou Univ, Dept Clin Lab, Affiliated Hosp 1, Zhengzhou, Peoples R China
[2] Key Clin Lab Henan Prov, Dept Clin Lab, Zhengzhou, Peoples R China
基金
美国国家科学基金会;
关键词
Exosomes; gastric cancer; invasion; metastasis; chemotherapy; CELL-DERIVED EXOSOMES; INTERCELLULAR COMMUNICATION; EXTRACELLULAR VESICLES; TUMOR-GROWTH; MICRORNA; RNA; MICROVESICLES; APOPTOSIS; BIOMARKER; MICROENVIRONMENT;
D O I
10.1080/00365521.2016.1278458
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective: In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC). Material: Exosomes are vesicles of endocytic origin ranging from 30 to 100nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC. Results: In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes' potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC. Conclusions: Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.
引用
收藏
页码:499 / 504
页数:6
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