Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer

被引：54
作者：
Yan, Yunmeng [1 ,2 ]
Fu, Guangzhen [1 ,2 ]
Ye, Yafei [1 ,2 ]
Ming, Liang [1 ,2 ]
机构：
[1] Zhengzhou Univ, Dept Clin Lab, Affiliated Hosp 1, Zhengzhou, Peoples R China
[2] Key Clin Lab Henan Prov, Dept Clin Lab, Zhengzhou, Peoples R China
来源：
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY | 2017年 / 52卷 / 05期
基金：
美国国家科学基金会;
关键词：
Exosomes; gastric cancer; invasion; metastasis; chemotherapy; CELL-DERIVED EXOSOMES; INTERCELLULAR COMMUNICATION; EXTRACELLULAR VESICLES; TUMOR-GROWTH; MICRORNA; RNA; MICROVESICLES; APOPTOSIS; BIOMARKER; MICROENVIRONMENT;
D O I：
10.1080/00365521.2016.1278458
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Objective: In order to summarize the role of exosomes in invasion and metastasis in gastric cancer (GC). Material: Exosomes are vesicles of endocytic origin ranging from 30 to 100nm in size; they are composed of a lipid bilayer and contain DNA, mRNA, miRNA, circular RNA and multiple proteins. Recently, increasing evidence shows that exosomes play a crucial role in the tumorigenesis of GC. Results: In this review, we focus on the latest findings on GC exosomes, mainly summarizing their role in invasion and metastasis in GC. Then, exosomes' potential functions as novel diagnostic and therapeutic biomarkers for GC are briefly discussed. At last, we prospect the clinical application perspective of exosomes in GC. Conclusions: Exosomes play a vital role in gastric cancer carcinogenesis and metastasis.
引用
收藏
页码：499 / 504
页数：6
相关论文
共 72 条
[1]   Regulation of cancer metastasis by cell-free miRNAs [J].
Aleckovic, Masa ;
Kang, Yibin .
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2015, 1855 (01) :24-42
[2]   Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation Agents [J].
Alhasan, Ali H. ;
Patel, Pinal C. ;
Choi, Chung Hang J. ;
Mirkin, Chad A. .
SMALL, 2014, 10 (01) :186-192
[3]   Validating survivin as a cancer therapeutic target [J].
Altieri, DC .
NATURE REVIEWS CANCER, 2003, 3 (01) :46-54
[4]   TSPAN8, identified by Escherichia coli ampicillin secretion trap, is associated with cell growth and invasion in gastric cancer [J].
Anami, Katsuhiro ;
Oue, Naohide ;
Noguchi, Tsuyoshi ;
Sakamoto, Naoya ;
Sentani, Kazuhiro ;
Hayashi, Tetsutaro ;
Naito, Yutaka ;
Oo, Htoo Zarni ;
Yasui, Wataru .
GASTRIC CANCER, 2016, 19 (02) :370-380
[5]   Tumor exosome-mediated promotion of adhesion to mesothelial cells in gastric cancer cells [J].
Arita, Tomohiro ;
Ichikawa, Daisuke ;
Konishi, Hirotaka ;
Komatsu, Shuhei ;
Shiozaki, Atsushi ;
Ogino, Shinpei ;
Fujita, Yuji ;
Hiramoto, Hidekazu ;
Hamada, Junichi ;
Shoda, Katsutoshi ;
Kosuga, Toshiyuki ;
Fujiwara, Hitoshi ;
Okamoto, Kazuma ;
Otsuji, Eigo .
ONCOTARGET, 2016, 7 (35) :56855-56863
[6]   Tumour microvesicles contain retrotransposon elements and amplified oncogene sequences [J].
Balaj, Leonora ;
Lessard, Ryan ;
Dai, Lixin ;
Cho, Yoon-Jae ;
Pomeroy, Scott L. ;
Breakefield, Xandra O. ;
Skog, Johan .
NATURE COMMUNICATIONS, 2011, 2
[7]  
Bang YJ, 2010, LANCET, V376, P1302
[8]   Tumour exosomes inhibit binding of tumour-reactive antibodies to tumour cells and reduce ADCC [J].
Battke, Christina ;
Ruiss, Romana ;
Welsch, Ulrich ;
Wimberger, Pauline ;
Lang, Stephan ;
Jochum, Simon ;
Zeidler, Reinhard .
CANCER IMMUNOLOGY IMMUNOTHERAPY, 2011, 60 (05) :639-648
[9]   Membrane microparticles mediate transfer of P-glycoprotein to drug sensitive cancer cells [J].
Bebawy, M. ;
Combes, V. ;
Lee, E. ;
Jaiswal, R. ;
Gong, J. ;
Bonhoure, A. ;
Grau, G. E. R. .
LEUKEMIA, 2009, 23 (09) :1643-1649
[10]   Exosomes as divine messengers: are they the Hermes of modern molecular oncology? [J].
Braicu, C. ;
Tomuleasa, C. ;
Monroig, P. ;
Cucuianu, A. ;
Berindan-Neagoe, I. ;
Calin, G. A. .
CELL DEATH AND DIFFERENTIATION, 2015, 22 (01) :34-45
12345678