An autonomous DNA nanomotor powered by a DNA enzyme

被引:193
作者
Chen, Y [1 ]
Wang, MS [1 ]
Mao, CD [1 ]
机构
[1] Purdue Univ, Dept Chem, W Lafayette, IN 47907 USA
关键词
catalytic DNA; DNA; nanotechnology; RNA; self-assembly;
D O I
10.1002/anie.200453779
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The power of life: An autonomous DNA nanomotor powered by an RNA-cleaving DNA enzyme (see figure) has been constructed that works in the same way as cellular protein motors: it continuously extracts chemical energy from fuel molecules to power mechanical motions. The fuel for the DNA nanomotor is the RNA substrate of the DNA enzyme.
引用
收藏
页码:3554 / 3557
页数:4
相关论文
共 31 条
[1]   MOLECULAR COMPUTATION OF SOLUTIONS TO COMBINATORIAL PROBLEMS [J].
ADLEMAN, LM .
SCIENCE, 1994, 266 (5187) :1021-1024
[2]   DNA duplex-quadruplex exchange as the basis for a nanomolecular machine [J].
Alberti, P ;
Mergny, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :1569-1573
[3]   The cell as a collection of protein machines: Preparing the next generation of molecular biologists [J].
Alberts, B .
CELL, 1998, 92 (03) :291-294
[4]  
[Anonymous], 1999, The RNA World: The Nature of Modern RNA Suggests a Prebiotic RNA
[5]   Photoinduction of fast, reversible translational motion in a hydrogen-bonded molecular shuttle [J].
Brouwer, AM ;
Frochot, C ;
Gatti, FG ;
Leigh, DA ;
Mottier, L ;
Paolucci, F ;
Roffia, S ;
Wurpel, GWH .
SCIENCE, 2001, 291 (5511) :2124-2128
[6]   Structure and function of the small ribozymes [J].
Butcher, SE .
CURRENT OPINION IN STRUCTURAL BIOLOGY, 2001, 11 (03) :315-320
[7]   A [2]catenane-based solid state electronically reconfigurable switch [J].
Collier, CP ;
Mattersteig, G ;
Wong, EW ;
Luo, Y ;
Beverly, K ;
Sampaio, J ;
Raymo, FM ;
Stoddart, JF ;
Heath, JR .
SCIENCE, 2000, 289 (5482) :1172-1175
[8]   Nanoelectromechanical systems [J].
Craighead, HG .
SCIENCE, 2000, 290 (5496) :1532-1535
[9]   Deoxyribozymes: new activities and new applications [J].
Emilsson, GM ;
Breaker, RR .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2002, 59 (04) :596-607
[10]  
Feng L., 2003, ANGEW CHEM, V115, P4478, DOI DOI 10.1002/ANGE.200351818