Enantioselective alkylation of aldehydes catalyzed by a highly active titanium complex of 3-substituted unsymmetric BINOL

被引：58

作者：

Harada, Toshiro ^{[1
]}

Kanda, Kousou ^{[1
]}

机构：

[1] Kyoto Inst Technol, Dept Chem & Mat Technol, Sakyo Ku, Kyoto 6068585, Japan

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 17期

基金：

美国国家科学基金会; 美国国家航空航天局; 英国科学技术设施理事会;

关键词：

D O I：

10.1021/ol061407x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A titanium complex derived from 3-(3,5-diphenylphenyl)-BINOL exhibits an enhanced catalytic activity in the asymmetric alkylation of aldehydes, allowing the reduction of the catalyst amount to less than 1 mol % without deterioration in enantioselectivity.

引用

页码：3817 / 3819

页数：3

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