Is Autophagy Dysfunction a Key to Exfoliation Glaucoma?

被引：14

作者：

Wolosin, J. Mario ^{[1
]}

Ritch, Robert ^{[3
]}

Bernstein, Audrey M. ^{[1
,2
]}

机构：

[1] Icahn Sch Med Mt Sinai, Dept Ophthalmol, New York, NY 10029 USA

[2] Icahn Sch Med Mt Sinai, Dept Pharmacol & Syst Therapeut, New York, NY 10029 USA

[3] New York Eye & Ear Infirm Mt Sinai, Einhorn Clin Res Ctr, New York, NY USA

来源：

JOURNAL OF GLAUCOMA | 2018年 / 27卷 / 03期

关键词：

exfoliation glaucoma; Tenon fibroblasts; autophagy; microtubules; lysosomes; mitophagy; OXIDASE-LIKE; 1; PSEUDOEXFOLIATION SYNDROME; LYSYL OXIDASE; APOLIPOPROTEIN-E; LOXL1; SUSCEPTIBILITY; ASSOCIATIONS; VARIANTS; PROTEIN;

D O I：

10.1097/IJG.0000000000000606

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

In this short report we review previous work toward the identification of the protein and cellular sources of exfoliation glaucoma and described our recent finding on dysfunction of autophagy in Tenon capsule fibroblasts obtained from exfoliation syndrome glaucoma patients at the time of surgery and discuss the potential implications of these findings for understanding the cellular sources of the disease.

引用

页码：197 / 201

页数：5

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