Key factors associated with the under-prescription of statins in elderly coronary heart disease patients: Results from the ELIAGE and ELICOEUR surveys

Introduction: The reasons why statins are under-utilized in elderly patients remain poorly understood. The aim of this study was to identify the reasons given by cardiologist for the non-prescription of statins in elderly CHD patients. Methods: Two cross-sectional pharmaco-epidemiological surveys were carried out among French cardiologists. The sample consisted of 1148 coronary patients aged 35 to 69 years and 1489 patients aged >= 70 years. Patients' risk factors, medical history, treatments, lipid values and the physicians' various motives for the non-prescription of statins were recorded. Results: Patients not treated with statins reached 37% in the age-group >= 70 years and 14% in the age-group 35-69 years. The main reason given for statin non-prescription was the lack of a medical indication (2.5% of the age-group 35 -69 years and 14% of the age-group < 70 years). Among patients >= 70 years, the lack of indication was more often cited in the following conditions: 1) in very old patients (36% of lack of indication in the age-group > 85 years vs. 10% in 70-75 years), 2) when lipid values were not available (20% when data were not available vs. 9%) and 3) when the patient had no prior history of myocardial infarction (MI) (20% when no history of MI vs. 7%). These factors were not associated with lack of indication among patients < 70 years. History of intolerance or side effect was given for 1.3% and 14% of patients for each of the groups (35-69 and > 70) and poor overall patient adherence was cited in 1% and 2%, respectively. Conclusion: The primary reason for the under-prescription of statins in elderly coronary patients is the perceived lack of indication, which stresses the need of extensive guidelines for prescription in elderly patients. Several factors associated with this perception seem to be specific to the elderly. (c) 2005 Elsevier Ireland Ltd. All rights reserved.