Human- and Virus-Encoded microRNAs as Potential Targets of Antiviral Therapy

被引：20

作者：

Kurzynska-Kokorniak, Anna ^{[1
]}

Jackowiak, Paulina ^{[1
]}

Figlerowicz, Magdalena ^{[2
]}

Figlerowicz, Marek ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-61704 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Infect Dis & Child Neurol, PL-60572 Poznan, Poland

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 08期

关键词：

microRNA; host-virus interaction; antiviral therapy; antagomiR; miRNA mimetic; target protector; artificial miRNA; VIRAL GENE-EXPRESSION; RNA INTERFERENCE; MESSENGER-RNAS; IN-VIVO; CELLULAR MICRORNAS; IDENTIFICATION; DELIVERY; SUPPRESSION; DROSOPHILA; PEPTIDE;

D O I：

10.2174/138955709788681573

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

It has recently been demonstrated that short RNA molecules, called microRNAs, are one of the major factors regulating the expression of human genes. There are several lines of evidence that microRNAs also play a key role in host-virus interactions. It is believed that both human- and virus-encoded miRNA will, in the nearest future, become very attractive targets of antiviral therapy.

引用

页码：927 / 937

页数：11

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