Human- and Virus-Encoded microRNAs as Potential Targets of Antiviral Therapy

被引：20

作者：

Kurzynska-Kokorniak, Anna ^{[1
]}

Jackowiak, Paulina ^{[1
]}

Figlerowicz, Magdalena ^{[2
]}

Figlerowicz, Marek ^{[1
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, Noskowskiego 12-14, PL-61704 Poznan, Poland

[2] Poznan Univ Med Sci, Dept Infect Dis & Child Neurol, PL-60572 Poznan, Poland

来源：

MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2009年 / 9卷 / 08期

关键词：

microRNA; host-virus interaction; antiviral therapy; antagomiR; miRNA mimetic; target protector; artificial miRNA; VIRAL GENE-EXPRESSION; RNA INTERFERENCE; MESSENGER-RNAS; IN-VIVO; CELLULAR MICRORNAS; IDENTIFICATION; DELIVERY; SUPPRESSION; DROSOPHILA; PEPTIDE;

D O I：

10.2174/138955709788681573

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

It has recently been demonstrated that short RNA molecules, called microRNAs, are one of the major factors regulating the expression of human genes. There are several lines of evidence that microRNAs also play a key role in host-virus interactions. It is believed that both human- and virus-encoded miRNA will, in the nearest future, become very attractive targets of antiviral therapy.

引用

页码：927 / 937

页数：11

共 83 条

[1] Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo
Aigner, Achim
[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY, 2006,
[2] Suppression of RNA interference by adenovirus virus-associated RNA
Andersson, MG
Haasnoot, PCJ
Xu, N
Berenjian, S
Berkhout, B
Akusjärvi, G
[J]. JOURNAL OF VIROLOGY, 2005, 79 (15) : 9556 - 9565
[3] Adenovirus virus-associated RNA is processed to functional interfering RNAs involved in virus production
Aparicio, O
Razquin, N
Zaratiegui, M
Narvaiza, I
Fortes, P
[J]. JOURNAL OF VIROLOGY, 2006, 80 (03) : 1376 - 1384
[4] Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
Bagga, S
Bracht, J
Hunter, S
Massirer, K
Holtz, J
Eachus, R
Pasquinelli, AE
[J]. CELL, 2005, 122 (04) : 553 - 563
[5] MRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes
Behm-Ansmant, Isabelle
Rehwinkel, Jan
Doerks, Tobias
Stark, Alexander
Bork, Peer
Izaurralde, Elisa
[J]. GENES & DEVELOPMENT, 2006, 20 (14) : 1885 - 1898
[6] HIV-1 encoded candidate micro-RNAs and their cellular targets
Bennasser Y.
Le S.-Y.
Yeung M.L.
Jeang K.-T.
[J]. Retrovirology, 1 (1)
[7] A balancing act: Viruses and miRNAs
Berkhout, Ben
[J]. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2008, 107 (01) : 1 - 3
[8] Developmental defects by antisense-mediated inactivation of micro-RNAs 2 and 13 in Drosophila and the identification of putative target genes
Boutla, A
Delidakis, C
Tabler, M
[J]. NUCLEIC ACIDS RESEARCH, 2003, 31 (17) : 4973 - 4980
[9] Epstein-Barr virus MicroRNAs are evolutionarily conserved and differentially expressed
Cai, Xuezhong
Schafer, Alexandra
Lu, Shihua
Bilello, John P.
Desrosiers, Ronald C.
Edwards, Rachel
Raab-Traub, Nancy
Cullen, Bryan R.
[J]. PLOS PATHOGENS, 2006, 2 (03) : 236 - 247
[10] Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells
Cai, XZ
Lu, SH
Zhang, ZH
Gonzalez, CM
Damania, B
Cullen, BR
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (15) : 5570 - 5575

← 1 2 3 4 5 6 7 8 9 →