E-cadherin in gastric cancer

被引：86

作者：

Chan, Annie On On ^{[1
]}

机构：

[1] Univ Hong Kong, Queen Mary Hosp, Dept Med, Div Gastroenterol & Hepatol, Hong Kong, Hong Kong, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2006年 / 12卷 / 02期

关键词：

E-cadherin; gastric cancer;

D O I：

10.3748/wjg.v12.i2.199

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Cadherin is an adhesion molecule and a superfamily of calcium-mediated membrane glycoproteins. E-cadherin is the prototype of the class E-cadherin that links to catenins to form the cytoskeleton. Recent evidence has shown that E-cadherin not only acts as an adhesive, but also plays important roles in growth development and carcinogenesis. It has been recently viewed as an invasion as well as a growth suppressor gene. This review summarizes the recent discoveries on E-cadherin and its role in gastric cancer. In particular, our work on E-cadherin in gastric cancer, including its relation with Helicobacter pylori and clinical applications, are described in detail. (c) 2006 The WJG Press. All rights reserved.

引用

页码：199 / 203

页数：5

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