Role of Inducible Nitric Oxide Synthase in Rostral Ventrolateral Medulla in Blood Pressure Regulation in Spontaneously Hypertensive Rats

被引：21
作者：
Kimura, Yoshikuni [1 ]
Hirooka, Yoshitaka [1 ]
Kishi, Takuya [1 ]
Ito, Koji [1 ]
Sagara, Yoji [1 ]
Sunagawa, Kenji [1 ]
机构：
[1] Kyushu Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Higashi Ku, Fukuoka 8128582, Japan
来源：
CLINICAL AND EXPERIMENTAL HYPERTENSION | 2009年 / 31卷 / 03期
关键词：
blood pressure; heart rate; brain; nitric oxide; sympathetic nervous system; OXIDATIVE STRESS; BRAIN; EXPRESSION; OVEREXPRESSION; INFLAMMATION; CONTRIBUTES;
D O I：
10.1080/10641960902822534
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Nitric oxide (NO) in the brainstem modulates blood pressure (BP). Overexpression of inducible NO synthase (iNOS) in the rostral ventrolateral medulla (RVLM) increases BP in normotensive Wistar-Kyoto rats (WKY), but its role in BP regulation in spontaneously hypertensive rats (SHR) is unknown. We examined iNOS expression and the effect of iNOS inhibitors in the RVLM on BP and heart rate in SHR and WKY. iNOS levels in the RVLM were significantly higher in SHR than in WKY. Bilateral microinjection of aminoguanidine into the RVLM dose-dependently decreased BP and heart rate in SHR, but not in WKY. These findings suggest that iNOS expression in the RVLM of SHR contributes to increase BP.
引用
收藏
页码：281 / 286
页数：6
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