p38 MAP kinases in the heart

被引：147

作者：

Yokota, Tomohiro

Wang, Yibin

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Anesthesiol, Cardiovasc Res Labs, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Physiol & Med, Cardiovasc Res Labs, Los Angeles, CA 90095 USA

来源：

GENE | 2016年 / 575卷 / 02期

基金：

美国国家卫生研究院;

关键词：

p38 MAP kinase; Stress-signaling; Heart physiology; Heart failure; ACTIVATED PROTEIN-KINASE; NF-KAPPA-B; PREVENTS CARDIOMYOCYTE APOPTOSIS; TYROSINE PHOSPHATASE HEPTP; MYOCARDIAL-INFARCTION; SIGNAL-TRANSDUCTION; DNA-DAMAGE; CELL-DEATH; INDEPENDENT ACTIVATION; TRANSCRIPTION FACTOR;

D O I：

10.1016/j.gene.2015.09.030

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

p38 kinases are members of the mitogen-activated protein kinases (MAPK) with established contribution to a wide range of signaling pathways and different biological processes. The prototypic p38 MAPK, p38 alpha was originally identified as an essential signaling kinase for inflammatory cytokine production Extensive studies have now revealed that p38s have critical roles in many different tissues far beyond immune regulation and inflammatory responses. In this review, we will focus on the structure and molecular biology of p38s, and their specific roles in heart, especially regarding myocyte proliferation, apoptosis, and hypertrophic responses. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：369 / 376

页数：8

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