Relationship between blood manganese and bone mineral density and bone mineral content in adults: A population-based cross-sectional study

被引:22
作者
Wang, Chao [1 ]
Zhu, Yong [1 ]
Long, Haitao [1 ]
Ou, Mingning [1 ]
Zhao, Shushan [1 ,2 ]
机构
[1] Cent South Univ, Xiangya Hosp, Dept Orthopaed, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Hunan, Peoples R China
来源
PLOS ONE | 2022年 / 17卷 / 10期
基金
中国国家自然科学基金;
关键词
MITOCHONDRIAL DYSFUNCTION; EXPOSURE; OSTEOPOROSIS; ASSOCIATION; TOXICITY; COPPER; WOMEN; SPINE; ZINC;
D O I
10.1371/journal.pone.0276551
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Purpose It has been reported that bone is the primary organ for manganese (Mn) accumulation, but the association between manganese and bone loss remains debatable. Therefore, this study aimed to evaluate the relationship between blood manganese and bone mineral density/bone mineral content (BMD/BMC) by using a representative sample from the National Health and Nutrition Examination Survey (NHANES). Methods A total of 9732 subjects over the age of 18 with available data were enrolled in this study. The relationship between blood manganese and BMD/BMC of the total body, spine and femoral regions was evaluated using multivariate linear regression models. Subgroup analyses were also performed. Results We observed a negative association between blood manganese and BMD/BMC in the femoral neck and total body in the fully adjusted model, especially femoral neck BMD in women aged 50-70 years. Conclusion In brief, people exposed to manganese should be aware of the increased risk of osteopenia or osteoporosis. Besides, due to the lack of available data, there are no definite values for the tolerable upper intake level (UL), average requirement (AR) and population reference intake (PRI) of manganese. The results of our study may provide some references for the establishment of AR, PRI and UL of Mn.
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页数:18
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