p16INK4a as an adjunct test in cervical cytology

被引:0
作者
Vitkovic, L. [1 ]
Perisic, Z. [2 ]
Zamurovic, M. [3 ]
Mitic, N. [4 ]
Piperskis, V. [5 ]
Trajkovic, G. [6 ]
Cvejic, M. [7 ]
Perisic, M. [8 ]
机构
[1] Univ Kosovska Mitrov, Inst Histol & Embriol, Fac Med, Kosovska Mitrovica, Serbia
[2] Univ Belgrade, Fac Med, Belgrade, Serbia
[3] Univ Clin Obstet & Gynecol Narodni Front, Belgrade 11000, Serbia
[4] Univ Kosovska Mitrov, Inst Pathol, Fac Med, Kosovska Mitrovica, Serbia
[5] Sci Res Ctr Galenika AD, Belgrade, Serbia
[6] Univ Belgrade, Fac Med, Inst Biostat & Bioinformat, Belgrade, Serbia
[7] Clin Ctr Nis, Neurol Clin, Belgrade, Serbia
[8] Clin Ctr Belgrade, Inst Obstet & Gynecol, Belgrade, Serbia
关键词
P16INK4A biomarker; Cervical cytology; HPV; ATYPICAL SQUAMOUS-CELLS; HUMAN-PAPILLOMAVIRUS; P16(INK4A) EXPRESSION; UTERINE CERVIX; INTRAEPITHELIAL NEOPLASIA; UNDETERMINED SIGNIFICANCE; P16; PROTEIN; PAP-SMEAR; LESIONS; MARKER;
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: This study investigated the correlation between cervical cytology, the expression of P16INK4a, and human papilloma virus (HPV) infection. Materials and Methods: The study included 100 subjects with suspected pathological cervical lesions. Cervical smears were analyzed for malignancy and p16INK4a. Histological finding represented "the golden standard". Results: Immunocytochemical analysis of protein p16INK4a expression on epithelial cells of cervical smear demonstrated increased p16INK4a expression in 36.0% of subjects. There was statistically significant positive correlation (Spearman r = 0.70; p < 0.001) between the pathological findings and the intensity of p16INK4a protein expression inside the epithelial cells, as well as with the histological finding (Spearman r = 0.71; p < 0.001). The intensity of p16INK4a protein expression in cytology finding was significantly higher in HPV16 positive patients (Mann-Whitney test, p = 0.0065). Conclusion: Good correlation between the expression rate and the severity of lesions indicates that this test might improve the results of cytology and HPV screening, as well as the results of predicting the prognosis of the disorder of the cervix.
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页码:685 / 689
页数:5
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