Leptin signaling

被引：327

作者：

Ahima, RS ^{[1
]}

Osei, SY ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2004年 / 81卷 / 02期

关键词：

leptin; obesity; feeding; hypothalamus; neuropeptide;

D O I：

10.1016/j.physbeh.2004.02.014

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：223 / 241

页数：19

共 220 条

[21] Effect of fasting on serum leptin in normal human subjects [J].

Boden, G ;

Chen, X ;

Mozzoli, M ;

Ryan, I .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (09) :3419-3423

[22] Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland - Leptin inhibits cortisol release directly [J].

Bornstein, SR ;

Uhlmann, K ;

Haidan, A ;

EhrhartBornstein, M ;

Scherbaum, WA .

DIABETES, 1997, 46 (07) :1235-1238

[23] Plasma leptin levels are increased in survivors of acute sepsis: Associated loss of diurnal rhythm in cortisol and leptin secretion [J].

Bornstein, SR ;

Licinio, J ;

Tauchnitz, R ;

Engelmann, L ;

Negrao, AB ;

Gold, P ;

Chrousos, GP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (01) :280-283

[24]

Broberger C, 1998, J COMP NEUROL, V402, P460

[25] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[26] Effects of pinealectomy and exogenous melatonin on serum leptin levels in male rat [J].

Canpolat, S ;

Sandal, S ;

Yilmaz, B ;

Yasar, A ;

Kutlu, S ;

Baydas, G ;

Kelestimur, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 428 (01) :145-148

[27] Decreased cerebrospinal-fluid/serum leptin ratio in obesity: A possible mechanism for leptin resistance [J].

Caro, JF ;

Kolaczynski, JW ;

Nyce, MR ;

Ohannesian, JP ;

Opentanova, I ;

Goldman, WH ;

Lynn, RB ;

Zhang, PL ;

Sinha, MK ;

Considine, RV .

LANCET, 1996, 348 (9021) :159-161

[28] Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor [J].

Carpenter, LR ;

Farruggella, TJ ;

Symes, A ;

Karow, ML ;

Yancopoulos, GD ;

Stahl, N .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (11) :6061-6066

[29] Regulation of in vivo growth hormone secretion by leptin. [J].

Carro, E ;

Senaris, R ;

Considine, RV ;

Casanueva, FF ;

Dieguez, C .

ENDOCRINOLOGY, 1997, 138 (05) :2203-2206

[30] Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion [J].

Carro, E ;

Señarís, RM ;

Seoane, LM ;

Frohman, LA ;

Arimura, A ;

Casanueva, FF ;

Diéguez, C .

NEUROENDOCRINOLOGY, 1999, 69 (01) :3-10

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