A chemoenzymatic route to N-acetylglucosamine-1-phosphate analogues: substrate specificity investigations of N-acetylhexosamine 1-kinase

被引：70

作者：

Cai, Li ^{[1
,2
]}

Guan, Wanyi ^{[1
,2
,3
,4
]}

Kitaoka, Motomitsu ^{[5
]}

Shen, Jie ^{[1
,2
]}

Xia, Chengfeng ^{[1
,2
]}

Chen, Wenlan ^{[1
,2
]}

Wang, Peng George ^{[1
,2
]}

机构：

[1] Ohio State Univ, Dept Chem, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Biochem, Columbus, OH 43210 USA

[3] Shandong Univ, Natl Glycoengn Res Ctr, Jinan 250100, Peoples R China

[4] Shandong Univ, State Key Lab Microbial Technol, Jinan 250100, Peoples R China

[5] Natl Agr & Food Res Org, Natl Food Res Inst, Tsukuba, Ibaraki 3058642, Japan

来源：

CHEMICAL COMMUNICATIONS | 2009年 / 20期

关键词：

DERIVATIVES; METABOLISM; PATHWAY; ACYL;

D O I：

10.1039/b904853g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reports an efficient chemoenzymatic production of an N-acetylhexosamine 1-phophate analogues library by N-acetylhexosamine 1-kinase (NahK) and describes the respective substrate specificity on this enzyme.

引用

页码：2944 / 2946

页数：3

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