N6-methyladenosine modifications: interactions with novel RNA-binding proteins and roles in signal transduction

被引：62

作者：

Chen, Jiaxin ^{[1
,2
]}

Fang, Xiao ^{[2
,3
]}

Zhong, Pengcheng ^{[1
,2
]}

Song, Zhangfa ^{[2
,4
]}

Hu, Xiaotong ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Sir Run Shaw Hosp, Biomed Res Ctr, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Sir Run Shaw Hosp, Key Lab Biotherapy Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sir Run Shaw Hosp, Dept Anesthesiol, Hangzhou, Zhejiang, Peoples R China

[4] Zhejiang Univ, Sir Run Shaw Hosp, Dept Colorectal Surg, Hangzhou, Zhejiang, Peoples R China

来源：

RNA BIOLOGY | 2019年 / 16卷 / 08期

基金：

中国国家自然科学基金;

关键词：

M6a reader; RNA-binding protein; protein domain; signaling pathway; MESSENGER-RNA; N-6-METHYLADENOSINE M(6)A; STEM-CELLS; METHYLATION; TRANSLATION; REVEALS; PATHWAY; METHYLTRANSFERASE; DIFFERENTIATION; DEMETHYLATION;

D O I：

10.1080/15476286.2019.1620060

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

RNA epigenetics has received a great deal of attention in recent years, and the reversible N6-methyladenosine (m6A) modification on messenger RNAs (mRNAs) has emerged as a widespread phenomenon. The vital roles of m6A in diverse biological processes are dependent on many RNA-binding proteins (RBPs) with reader' or nonreader' functions. Moreover, m6A effector proteins affect cellular processes, such as stem cell differentiation, tumor development and the immune response by controlling signal transduction. This review provides an overview of the interactions of m6A with various RBPs, including the reader' proteins (excluding the YT521-B homology (YTH) domain proteins and the heterogeneous nuclear ribonucleoproteins (hnRNPs)), and the functional nonreader' proteins, and this review focuses on their specific RNA-binding domains and their associations with other m6A effectors. Furthermore, we summarize key m6A-marked targets in distinct signaling pathways, leading to a better understanding of the cellular m6A machinery.

引用

页码：991 / 1000

页数：10

共 101 条

[1] Cap-specific terminal N6-methylation of RNA by an RNA polymerase II-associated methyltransferase [J].

Akichika, Shinichiro ;

Hirano, Seiichi ;

Shichino, Yuichi ;

Suzuki, Takeo ;

Nishimasu, Hiroshi ;

Ishitani, Ryuichiro ;

Sugita, Ai ;

Hirose, Yutaka ;

Iwasaki, Shintaro ;

Nureki, Osamu ;

Suzuki, Tsutomu .

SCIENCE, 2019, 363 (6423) :141-141

[2] HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events [J].

Alarcon, Claudio R. ;

Goodarzi, Hani ;

Lee, Hyeseung ;

Liu, Xuhang ;

Tavazoie, Saeed ;

Tavazoie, Sohail F. .

CELL, 2015, 162 (06) :1299-1308

[3] RNA Chemical Proteomics Reveals the N6-Methyladenosine (m6A)-Regulated Protein-RNA Interactome [J].

Arguello, A. Emilia ;

DeLiberto, Amanda N. ;

Kleiner, Ralph E. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2017, 139 (48) :17249-17252

[4] Alternative splicing as a regulator of development and tissue identity [J].

Baralle, Francisco E. ;

Giudice, Jimena .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2017, 18 (07) :437-451

[5] Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control [J].

Barbieri, Isaia ;

Tzelepis, Konstantinos ;

Pandolfini, Luca ;

Shi, Junwei ;

Millan-Zambrano, Gonzalo ;

Robson, Samuel C. ;

Aspris, Demetrios ;

Migliori, Valentina ;

Bannister, Andrew J. ;

Han, Namshik ;

De Braekeleer, Etienne ;

Ponstingl, Hannes ;

Hendrick, Alan ;

Vakoc, Christopher R. ;

Vassiliou, George S. ;

Kouzarides, Tony .

NATURE, 2017, 552 (7683) :126-+

[6] m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells [J].

Batista, Pedro J. ;

Molinie, Benoit ;

Wang, Jinkai ;

Qu, Kun ;

Zhang, Jiajing ;

Li, Lingjie ;

Bouley, Donna M. ;

Lujan, Ernesto ;

Haddad, Bahareh ;

Daneshvar, Kaveh ;

Carter, Ava C. ;

Flynn, Ryan A. ;

Zhou, Chan ;

Lim, Kok-Seong ;

Dedon, Peter ;

Wernig, Marius ;

Mullen, Alan C. ;

Xing, Yi ;

Giallourakis, Cosmas C. ;

Chang, Howard Y. .

CELL STEM CELL, 2014, 15 (06) :707-719

[7] FTO: linking m6A demethylation to adipogenesis [J].

Ben-Haim, Moshe Shay ;

Moshitch-Moshkovitz, Sharon ;

Rechavi, Gideon .

CELL RESEARCH, 2015, 25 (01) :3-4

[8] The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency [J].

Bertero, Alessandro ;

Brown, Stephanie ;

Madrigal, Pedro ;

Osnato, Anna ;

Ortmann, Daniel ;

Yiangou, Loukia ;

Kadiwala, Juned ;

Hubner, Nina C. ;

de los Mozos, Igor Ruiz ;

Sadee, Christoph ;

Lenaerts, An-Sofie ;

Nakanoh, Shota ;

Grandy, Rodrigo ;

Farnell, Edward ;

Ule, Jernej ;

Stunnenberg, Hendrik G. ;

Mendjan, Sasha ;

Vallier, Ludovic .

NATURE, 2018, 555 (7695) :256-+

[9] Dynamic Integration of Splicing within Gene Regulatory Pathways [J].

Braunschweig, Ulrich ;

Gueroussov, Serge ;

Plocik, Alex M. ;

Graveley, Brenton R. ;

Blencowe, Benjamin J. .

CELL, 2013, 152 (06) :1252-1269

[10] The oncogenic triangle of HMGA2, LIN28B and IGF2BP1 antagonizes tumor-suppressive actions of the let-7 family [J].

Busch, Bianca ;

Bley, Nadine ;

Mueller, Simon ;

Glass, Markus ;

Misiak, Danny ;

Lederer, Marcell ;

Vetter, Martina ;

Strauss, Hans-Georg ;

Thomssen, Christoph ;

Huettelmaier, Stefan .

NUCLEIC ACIDS RESEARCH, 2016, 44 (08) :3845-3864

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