Prostate cancer Important steps and considerations in the design of therapeutic vaccines

被引：0

作者：

McArdle, Stephanie E. B. ^{[1
]}

Pockley, A. Graham ^{[1
]}

Gibson, Glen R. ^{[2
]}

Rees, Robert C. ^{[1
]}

机构：

[1] Nottingham Trent Univ, John van Geest Canc Res Ctr, Nottingham, England

[2] Univ Reading, Reading, Berks, England

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 02期

关键词：

prostate; animal model; cancer vaccine; stress; microbiota; clinical trial; MODULATION; STRESS;

D O I：

10.4161/onci.28049

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vaccine-based immunotherapy can increase the overall survival of patients with advanced prostate cancer. However, the efficacy of vaccine-elicited anticancer immune responses is heavily influenced by the physical, nutritional, and psychological status of the patient. Given their importance, these parameters should be carefully considered for the design of future clinical trials testing this immunotherapeutic paradigm in prostate cancer patients.

引用

页数：3

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