Biocompatibility of poly(ε-caprolactone)/poly(ethylene glycol) diblock copolymers with nanophase separation

被引：62

作者：

Hsu, SH ^{[1
]}

Tang, CM

Lin, CC

机构：

[1] Natl Chung Hsing Univ, Dept Chem Engn, Taichung 40227, Taiwan

[2] Natl Chung Hsing Univ, Dept Chem, Taichung 40227, Taiwan

来源：

BIOMATERIALS | 2004年 / 25卷 / 25期

关键词：

PCL/PEG diblock copolymer; microphase separation; nanotopography; cell responses inflammation; platelet activation;

D O I：

10.1016/j.biomaterials.2004.01.061

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this study, we prepared diblock copolymers of poly(epsilon-caprolactone) (PCL) and poly(ethylene glycol) (PEG) by aluminum alkoxide catalysts. The biological responses to the spin cast surface of different PCL/PEG diblock copolymers were investigated in vitro. Our results showed that Surface hydrophilicity improved with the increased PEG segments in diblock copolymers and that bacteria adhesion was inhibited by increased PEG contents. PCL-PEG 23:77 showed nanotopography on the surface. The number of adhered endothelial cells, platelets and monocytes on diblock copolymer surfaces was inhibited in PCL-PEG 77:23 and enhanced in PCL-PEG 23:77. Nevertheless, the platelet and monocyte activation on PCL-PEG 23:77 was reduced. PCL-PEG 23:77 had better cellular response as well as lower degree of platelet and monocyte activation. The current study was the first one to demonstrate that surface nanotopography could influence not only cell adhesion and growth but also platelet and monocyte activation. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：5593 / 5601

页数：9

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