99mTc-Fab′ Fragments (Sulesomab) for Imaging Septically Loosened Total Knee Arthroplasty

被引：15

作者：

Gratz, S. ^{[1
,2
]}

Behr, T. M. ^{[2
]}

Reize, P. ^{[3
]}

Pfestroff, A. ^{[2
]}

Kampen, W. U. ^{[4
]}

Hoeffken, H. ^{[2
]}

机构：

[1] Ctr Bad Cannstatt, Dept Nucl Med, D-70372 Stuttgart, Germany

[2] Univ Marburg, Dept Nucl Med, Marburg, Germany

[3] Ctr Bad Cannstatt, Dept Trauma Reconstruct & Orthopaed Surg, D-70372 Stuttgart, Germany

[4] Ctr Spitaler Hof, Dept Nucl Med Spitaler Hof, Hamburg, Germany

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 2009年 / 37卷 / 01期

关键词：

TOTAL KNEE ARTHROPLASTY (TKA); DIAGNOSTIC IMAGING; (TC)-T-99M-FAB ' FRAGMENTS; SULESOMAB; INFECTIONS; POLYCLONAL HUMAN-IMMUNOGLOBULIN; BLOOD-CELL SCINTIGRAPHY; MONOCLONAL-ANTIBODIES; IN-111; LEUKOCYTE; BW; 250/183; TOTAL HIP; DIAGNOSIS; INFECTIONS; PROSTHESIS; OSTEOMYELITIS;

D O I：

10.1177/147323000903700107

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The diagnostic accuracy of infection scintigraphy with Tc-99m-labelled monoclonal antibody Fab' fragments (sulesomab) was studied in patients with suspected total knee arthroplasty (TKA) infection. Images from 26 patients were evaluated by two independent readers and compared with a quantitative interpretation of time-activity courses. Microbiological examinations and joint aspiration results were used as reference standards. Histologically, aseptic TKA loosening occurred in two patients and severe, moderate or mild septic loosening in four, nine and 11 patients, respectively. Diagnostic accuracy for severe infection was 100% for both readers, whereas for moderate infection accuracy decreased by 12% and 12% for readers one and two, respectively. For mild infection a further decrease of approximately 61% and 52% occurred for readers one and two, respectively. Quantitative evaluation gave significantly better results over visual interpretation with a diagnostic accuracy of 100% for severe infection and decreased by only 10% and 15% in patients with moderate and mild infection, respectively. Quantitative evaluation of Tc-99m-Fab' fragments is highly sensitive and specific for diagnostic imaging of infection in patients with septically-loosened TKA.

引用

页码：54 / 67

页数：14

共 35 条

[1] KINETIC DATA OF INVIVO LABELED GRANULOCYTES IN HUMANS WITH A MURINE TC-99M-LABELED MONOCLONAL-ANTIBODY [J].

BECKER, W ;

BORST, U ;

FISCHBACH, W ;

PASURKA, B ;

SCHAFER, R ;

BORNER, W .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1989, 15 (07) :361-366

[2] THE SINGLE LATE TC-99(M) GRANULOCYTE ANTIBODY SCAN IN INFLAMMATORY DISEASES [J].

BECKER, WS ;

SAPTOGINO, A ;

WOLF, FG .

NUCLEAR MEDICINE COMMUNICATIONS, 1992, 13 (03) :186-192

[3]

DANIELS AU, 1998, CAMPBELLS OPERATIVE, P211

[4] Comparison between Leukoscan® (Sulesomab) and Gallium-67 for the diagnosis of osteomyelitis in the diabetic foot [J].

Delcourt, A ;

Huglo, D ;

Prangere, T ;

Benticha, H ;

Devemy, F ;

Tsirtsikoulou, D ;

Lepeut, M ;

Fontaine, P ;

Steinling, M .

DIABETES & METABOLISM, 2005, 31 (02) :125-132

[5]

Fleiss J.L., 1981, Statistical methods for rates and proportions, 2Statistical methods for rates and proportions, P22, DOI [10.1002/0471445428.ch18, DOI 10.1002/0471445428.CH18]

[6]

GOLDENBERG DM, 1992, J NUCL MED, V33, P803

[7]

GOLDENBERG DM, 1990, CANCER RES S, V50, P909

[8] LeukoScan for imaging infection in different clinical settings -: A retrospective evaluation and extended review of the literature [J].

Gratz, S ;

Schipper, ML ;

Dörner, J ;

Höffken, H ;

Becker, W ;

Kaiser, JW ;

Béhé, M ;

Behr, TM .

CLINICAL NUCLEAR MEDICINE, 2003, 28 (04) :267-276

[9] 99mTC-labelled antigranulocyte monoclonal antibody FAB' fragments versus echocardiography in the diagnosis of subacute infective endocarditis [J].

Gratz, S ;

Raddatz, D ;

Hagenah, G ;

Behr, T ;

Béhé, M ;

Becker, W .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 2000, 75 (01) :75-84

[10]

GUYTON JL, 1998, CAMPBELLS OPERATIVE, P232

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