Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells

被引：305

作者：

Hishikawa, Daisuke ^{[1
]}

Hashidate, Tomomi ^{[1
]}

Shimizu, Takao ^{[1
,2
]}

Shindou, Hideo ^{[1
,3
]}

机构：

[1] Natl Ctr Global Hlth & Med, Res Inst, Dept Lipid Signaling, Tokyo 1628655, Japan

[2] Univ Tokyo, Dept Biochem & Mol Biol, Fac Med, Tokyo 1130033, Japan

[3] Japan Sci & Technol Agcy, CREST, Kawaguchi, Saitama 3320012, Japan

来源：

JOURNAL OF LIPID RESEARCH | 2014年 / 55卷 / 05期

基金：

日本科学技术振兴机构;

关键词：

lysophospholipid acyltransferase; membrane biology; phospholipid metabolism; LYSOPHOSPHATIDIC ACID ACYLTRANSFERASE; ACTIVATING-FACTOR PRODUCTION; ACYL-COA; ARACHIDONIC-ACID; LYSOPHOSPHOLIPID ACYLTRANSFERASE; INTRAMITOCHONDRIAL TRANSPORT; MITOCHONDRIAL DYSFUNCTION; PHOSPHATIDIC-ACID; LIPID MEDIATORS; GOLGI-COMPLEX;

D O I：

10.1194/jlr.R046094

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular membranes are composed of numerous kinds of glycerophospholipids with different combinations of polar heads at the sn-3 position and acyl moieties at the sn-1 and sn-2 positions, respectively. The glycerophospholipid compositions of different cell types, organelles, and inner/outer plasma membrane leaflets are quite diverse. The acyl moieties of glycerophospholipids synthesized in the de novo pathway are subsequently remodeled by the action of phospholipases and lysophospholipid acyltransferases. This remodeling cycle contributes to the generation of membrane glycerophospholipid diversity and the production of lipid mediators such as fatty acid derivatives and lysophospholipids. Furthermore, specific glycerophospholipid transporters are also important to organize a unique glycerophospholipid composition in each organelle. Recent progress in this field contributes to understanding how and why membrane glycerophospholipid diversity is organized and maintained.

引用

页码：799 / 807

页数：9

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