Understanding the tumor immune microenvironment (TIME) for effective therapy

被引：4020

作者：

Binnewies, Mikhail ^{[1
]}

Roberts, Edward W. ^{[1
]}

Kersten, Kelly ^{[1
]}

Chan, Vincent ^{[2
]}

Fearon, Douglas F. ^{[3
]}

Merad, Miriam ^{[4
]}

Coussens, Lisa M. ^{[5
]}

Gabrilovich, Dmitry I. ^{[6
]}

Ostrand-Rosenberg, Suzanne ^{[7
,8
,9
]}

Hedrick, Catherine C. ^{[10
]}

Vonderheide, Robert H. ^{[11
]}

Pittet, Mikael J. ^{[12
]}

Jain, Rakesh K. ^{[13
,14
]}

Zou, Weiping ^{[15
]}

Howcroft, T. Kevin ^{[16
]}

Woodhouse, Elisa C. ^{[16
]}

Weinberg, Robert A. ^{[17
]}

Krummel, Matthew F. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Dept Pathol, San Francisco, CA 94140 USA

[2] Univ Calif San Francisco, UCSF Immunoprofiler Initiat, San Francisco, CA 94143 USA

[3] Cold Spring Harbor Lab, POB 100, Cold Spring Harbor, NY 11724 USA

[4] Icahn Sch Med Mt Sinai, Precis Immunol Inst, New York, NY 10029 USA

[5] Oregon Hlth & Sci Univ, Dept Cell Dev & Canc Biol, Portland, OR 97201 USA

[6] Wistar Inst Anat & Biol, 3601 Spruce St, Philadelphia, PA 19104 USA

[7] Univ Maryland Baltimore Cty, Dept Biol Sci, Baltimore, MD 21228 USA

[8] Univ Utah, Huntsman Canc Inst, Salt Lake City, UT USA

[9] Univ Utah, Dept Pathol, Salt Lake City, UT USA

[10] La Jolla Inst Allergy & Immunol, Div Inflammat Biol, La Jolla, CA USA

[11] Univ Penn, Dept Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

[12] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

[13] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Labs Tumor Biol, Boston, MA 02114 USA

[14] Harvard Med Sch, Boston, MA USA

[15] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI USA

[16] NCI, Div Canc Biol, NIH, Bethesda, MD 20892 USA

[17] Whitehead Inst Biomed Res, 9 Cambridge Ctr, Cambridge, MA 02142 USA

来源：

NATURE MEDICINE | 2018年 / 24卷 / 05期

关键词：

TERTIARY LYMPHOID STRUCTURES; T-CELL DYSFUNCTION; BREAST-CANCER; DENDRITIC CELLS; COLORECTAL-CANCER; MACROPHAGE ACTIVATION; MOLECULAR SUBTYPES; PANCREATIC-CANCER; LABORATORY MICE; PROMOTES;

D O I：

10.1038/s41591-018-0014-x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The clinical successes in immunotherapy have been both astounding and at the same time unsatisfactory. Countless patients with varied tumor types have seen pronounced clinical response with immunotherapeutic intervention; however, many more patients have experienced minimal or no clinical benefit when provided the same treatment. As technology has advanced, so has the understanding of the complexity and diversity of the immune context of the tumor microenvironment and its influence on response to therapy. It has been possible to identify different subclasses of immune environment that have an influence on tumor initiation and response and therapy; by parsing the unique classes and subclasses of tumor immune microenvironment (TIME) that exist within a patient's tumor, the ability to predict and guide immunotherapeutic responsiveness will improve, and new therapeutic targets will be revealed.

引用

页码：541 / 550

页数：10

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