Highly regioselective transformation of alkenyl bromides into α-bromoaziridines and α-bromohydrazones

被引：36

作者：

Krasnova, LB ^{[1
]}

Yudin, AK ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Davenport Res Labs, Toronto, ON M5S 3H6, Canada

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 10期

关键词：

D O I：

10.1021/ol060336z

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthetic utility of alpha.-halohydrazones is an underexplored area due to the lack of chemo- and regloselective routes towards these molecules. Herein, we describe a general method for alpha-bromohydrazone synthesis via the rearrangement of alpha-bromoaziridines, which can be readily prepared for the first time from the corresponding alkenyl bromides. The rearrangement of alpha-bromoaziridines into alpha-bromohydrazones proceeds with high yields and with high selectivities.

引用

页码：2011 / 2014

页数：4

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