Remission of multicentric reticulohistiocytosis by combined therapy with infliximab

Multicentric reticulohistiocytosis is an extremely rare systemic disorder of unknown etiology. It is characterized by a severe symmetric polyarthritis which can progresses to a mutilant arthritis and papulonodular skin and mucosal lesions. The diagnostic of multicentric reticulo histiocytosis is histopathologic. Approximately one-third of the adults patients have association with malignancies. There is no uniform treatment regimen for multicentric reticulohistiocytosis. We present a case of a 46-year woman with a classical clinical picture of multicentric reticulohistiocytosis. The patient received treatment with biological immunemodulators with marked results.