Low Glucose Utilization and Neurodegenerative Changes Caused by Sodium Fluoride Exposure in Rat's Developmental Brain

被引：70

作者：

Jiang, Chunyang ^{[1
,2
,3
]}

Zhang, Shun ^{[1
,2
]}

Liu, Hongliang ^{[4
]}

Guan, Zhizhong ^{[5
]}

Zeng, Qiang ^{[4
]}

Zhang, Cheng ^{[1
,2
]}

Lei, Rongrong ^{[1
,2
]}

Xia, Tao ^{[1
,2
]}

Wang, Zhenglun ^{[1
,2
]}

Yang, Lu ^{[1
,2
]}

Chen, Yihu ^{[1
,2
]}

Wu, Xue ^{[1
,2
]}

Zhang, Xiaofei ^{[1
,2
]}

Cui, Yushan ^{[4
]}

Yu, Linyu ^{[4
]}

Wang, Aiguo ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ, Dept Environm Hlth, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ, MOE Key Lab Environm & Hlth, Wuhan 430030, Hubei, Peoples R China

[3] Tianjin Union Med Ctr, Dept Thorac Surg, Tianjin 300121, Peoples R China

[4] Tianjin Ctr Dis Control & Prevent, Tianjin 300011, Peoples R China

[5] Guiyang Med Coll, Dept Pathol, Guiyang 550004, Guizhou, Peoples R China

来源：

NEUROMOLECULAR MEDICINE | 2014年 / 16卷 / 01期

关键词：

Sodium fluoride; F-18-fluorodeoxyglucose (FDG) PET/CT; MRI; Glucose utilization; Neuron degeneration; OXIDATIVE STRESS; EXPRESSION; APOPTOSIS; TOXICITY; MEMORY; NEUROTOXICITY; TRANSCRIPTION; HIPPOCAMPUS; MECHANISMS; HEALTH;

D O I：

10.1007/s12017-013-8260-z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Fluorine, a toxic and reactive element, is widely prevalent throughout the environment and can induce toxicity when absorbed into the body. This study was to explore the possible mechanisms of developmental neurotoxicity in rats treated with different levels of sodium fluoride (NaF). The rats' intelligence, as well as changes in neuronal morphology, glucose absorption, and functional gene expression within the brain were determined using the Morris water maze test, transmission electron microscopy, small-animal magnetic resonance imaging and Positron emission tomography and computed tomography, and Western blotting techniques. We found that NaF treatment-impaired learning and memory in these rats. Furthermore, NaF caused neuronal degeneration, decreased brain glucose utilization, decreased the protein expression of glucose transporter 1 and glial fibrillary acidic protein, and increased levels of brain-derived neurotrophic factor in the rat brains. The developmental neurotoxicity of fluoride may be closely associated with low glucose utilization and neurodegenerative changes.

引用

页码：94 / 105

页数：12

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