Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(II) complexes for photodynamic therapy

被引：58

作者：

Huang, Huaiyi ^{[1
]}

Zhang, Pingyu ^{[1
]}

Yu, Bole ^{[1
]}

Jin, Chengzhi ^{[1
]}

Ji, Liangnian ^{[1
]}

Chao, Hui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2015年 / 44卷 / 39期

基金：

国家高技术研究发展计划(863计划); 美国国家科学基金会;

关键词：

METAL-COMPLEXES; BIS(TERPYRIDINE) COMPLEXES; POLYPYRIDYL COMPLEXES; COPPER(II) COMPLEXES; ANTICANCER ACTIVITY; CRYSTAL-STRUCTURE; DNA INTERACTION; QUANTUM YIELD; PHOTOCLEAVAGE; PHOTOSENSITIZERS;

D O I：

10.1039/c5dt02081f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This study investigated the photodynamic therapy (PDT) and anticancer activity of mixed ligand Ru(II) terpyridyl complexes (Ru1-Ru3). The photophysical and photochemical properties, hydrophobic properties, DNA binding and DNA transcription inhibition abilities, cell uptake efficiency, cellular localization and photo-cytotoxicity were investigated. Ru1-Ru3 exhibited red luminescence between 670-710 nm and functioned as photo-sensitizers (PSs) by generating both singlet oxygen and radical ions. Without light activation, Ru1-Ru3 were located at the cytoplasm and were nontoxic to cells. However, upon light activation, Ru1-Ru3 exhibited significant photocytotoxicity. After PDT treatment, mitochondria alteration and nuclear membrane disruption occurred, which resulted in relocalization of the complexes from the cytoplasm to the nucleus. Moreover, high cellular oxidative stress caused cell necrocytosis after PDT treatment.

引用

页码：17335 / 17345

页数：11

共 40 条

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