Synthesis, characterization and biological evaluation of mixed-ligand ruthenium(II) complexes for photodynamic therapy

被引：57

作者：

Huang, Huaiyi ^{[1
]}

Zhang, Pingyu ^{[1
]}

Yu, Bole ^{[1
]}

Jin, Chengzhi ^{[1
]}

Ji, Liangnian ^{[1
]}

Chao, Hui ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China

来源：

DALTON TRANSACTIONS | 2015年 / 44卷 / 39期

基金：

美国国家科学基金会; 国家高技术研究发展计划(863计划);

关键词：

METAL-COMPLEXES; BIS(TERPYRIDINE) COMPLEXES; POLYPYRIDYL COMPLEXES; COPPER(II) COMPLEXES; ANTICANCER ACTIVITY; CRYSTAL-STRUCTURE; DNA INTERACTION; QUANTUM YIELD; PHOTOCLEAVAGE; PHOTOSENSITIZERS;

D O I：

10.1039/c5dt02081f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

This study investigated the photodynamic therapy (PDT) and anticancer activity of mixed ligand Ru(II) terpyridyl complexes (Ru1-Ru3). The photophysical and photochemical properties, hydrophobic properties, DNA binding and DNA transcription inhibition abilities, cell uptake efficiency, cellular localization and photo-cytotoxicity were investigated. Ru1-Ru3 exhibited red luminescence between 670-710 nm and functioned as photo-sensitizers (PSs) by generating both singlet oxygen and radical ions. Without light activation, Ru1-Ru3 were located at the cytoplasm and were nontoxic to cells. However, upon light activation, Ru1-Ru3 exhibited significant photocytotoxicity. After PDT treatment, mitochondria alteration and nuclear membrane disruption occurred, which resulted in relocalization of the complexes from the cytoplasm to the nucleus. Moreover, high cellular oxidative stress caused cell necrocytosis after PDT treatment.

引用

页码：17335 / 17345

页数：11

共 50 条

[1] Mixed-ligand nickel(II) thiosemicarbazone complexes: Synthesis, characterization and biological evaluation
Saswati
Dinda, Rupam
Schmiesing, Carla S.
Sinn, Ekkehard
Patil, Yogesh P.
Nethaji, M.
Stoeckli-Evans, Helen
Acharyya, Rama
POLYHEDRON, 2013, 50 (01) : 354 - 363
[2] Synthesis and Characterization of Some Ruthenium Mixed-Ligand Complexes
K. Q. Shawakfeh
N. A. F. Al-Rawashdeh
S. Khader
Russian Journal of Coordination Chemistry, 2002, 28 : 789 - 793
[3] Synthesis and characterization of some ruthenium mixed-ligand complexes
Shawakfeh, K.Q.
Al-Rawashdeh, N.A.F.
Khader, S.
Koordinatsionnaya Khimiya, 2002, 28 (11): : 841 - 845
[4] Synthesis and characterization of some ruthenium mixed-ligand complexes
Shawakfeh, KQ
Al-Rawashdeh, NAF
Khader, S
RUSSIAN JOURNAL OF COORDINATION CHEMISTRY, 2002, 28 (11) : 789 - 792
[5] Synthesis, characterization, photocleavage of DNA and cytotoxicity of ruthenium(II) mixed-ligand complexes
Liu, Yun-Jun
Zeng, Cheng-Hui
Wu, Fu-Hai
Yao, Jun-Hua
He, Li-Xin
Huang, Hong-Liang
JOURNAL OF MOLECULAR STRUCTURE, 2009, 932 (1-3) : 105 - 111
[6] Synthesis and characterization of ruthenium(II) azoimine-diphosphine mixed-ligand complexes
Al-Noaimi, Mousa
El-Barghouthi, Musa I.
El-Khateeb, Mohammad
Abdel-Rahman, Obada S.
Goerls, Helmar
Crutchley, Robert J.
POLYHEDRON, 2008, 27 (12) : 2698 - 2704
[7] Mixed-ligand complexes of ruthenium(II) incorporating a diazo ligand: Synthesis, characterization and DNA binding
Deshpande, MS
Kumbhar, AS
JOURNAL OF CHEMICAL SCIENCES, 2005, 117 (02) : 153 - 159
[8] Mixed-ligand complexes of ruthenium(II) incorporating a diazo ligand: Synthesis, characterization and DNA binding
Megha S Deshpande
Avinash S Kumbhar
Journal of Chemical Sciences, 2005, 117 (2) : 153 - 159
[9] SYNTHESIS AND CHARACTERIZATION OF MIXED-LIGAND CYCLOPENTADIENYL PYRAZOLYLBORATE COMPLEXES OF RUTHENIUM
MCNAIR, AM
BOYD, DC
MANN, KR
ORGANOMETALLICS, 1986, 5 (02) : 303 - 310
[10] Synthesis, characterization, and biological investigation of new mixed-ligand complexes
Amin, Basma H.
Abou-Dobara, Mohamed, I
Diab, Mostafa A.
Gomaa, Essam A.
El-Mogazy, Mohammed A.
El-Sonbati, Adel Z.
EL-Ghareib, Mohamed S.
Hussien, Mostafa A.
Salama, Hanaa M.
APPLIED ORGANOMETALLIC CHEMISTRY, 2020, 34 (08)

← 1 2 3 4 5 →