HPLC enantioseparation on a homochiral MOF-silica composite as a novel chiral stationary phase

被引：63
|
作者：
Tanaka, Koichi [1 ]
Muraoka, Toshihide [1 ]
Otubo, Yasuhiro [1 ]
Takahashi, Hiroki [2 ]
Ohnishi, Atsushi [3 ]
机构：
[1] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Suita, Osaka 5648680, Japan
[2] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan
[3] CPI Co, Daicel Corp, Himeji, Hyogo 6711283, Japan
来源：
RSC ADVANCES | 2016年 / 6卷 / 26期
关键词：
METAL-ORGANIC FRAMEWORKS; CARBON-DIOXIDE CAPTURE; CHROMATOGRAPHIC RESOLUTION; DESIGN; SULFOXIDES; CHEMISTRY;
D O I：
10.1039/c5ra26520g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The last frontier in the development of chiral stationary phases for chromatographic enantioseparation involves homochiral metal-organic frameworks (MOFs). Using enantiopure (R)-2,2'-dihydroxy-1,1'-binaphthalene- 6,60-dicarboxylic acid as a starting material, we prepared three homochiral MOFs that were further used as chiral stationary phases for high-performance liquid chromatography to separate the enantiomers of various kinds of racemic sulfoxides, sec-alcohols, beta-lactams, benzoins, flavanones and epoxides. The experimental results showed excellent performances for enantioseparation, and highlighted that enantioseparation on homochiral MOF columns is practical.
引用
收藏
页码：21293 / 21301
页数：9
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