HPLC enantioseparation on a homochiral MOF-silica composite as a novel chiral stationary phase

被引：63

作者：

Tanaka, Koichi ^{[1
]}

Muraoka, Toshihide ^{[1
]}

Otubo, Yasuhiro ^{[1
]}

Takahashi, Hiroki ^{[2
]}

Ohnishi, Atsushi ^{[3
]}

机构：

[1] Kansai Univ, Fac Chem Mat & Bioengn, Dept Chem & Mat Engn, Suita, Osaka 5648680, Japan

[2] Kyoto Univ, Grad Sch Human & Environm Studies, Kyoto 6068501, Japan

[3] CPI Co, Daicel Corp, Himeji, Hyogo 6711283, Japan

来源：

RSC ADVANCES | 2016年 / 6卷 / 26期

关键词：

METAL-ORGANIC FRAMEWORKS; CARBON-DIOXIDE CAPTURE; CHROMATOGRAPHIC RESOLUTION; DESIGN; SULFOXIDES; CHEMISTRY;

D O I：

10.1039/c5ra26520g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The last frontier in the development of chiral stationary phases for chromatographic enantioseparation involves homochiral metal-organic frameworks (MOFs). Using enantiopure (R)-2,2'-dihydroxy-1,1'-binaphthalene- 6,60-dicarboxylic acid as a starting material, we prepared three homochiral MOFs that were further used as chiral stationary phases for high-performance liquid chromatography to separate the enantiomers of various kinds of racemic sulfoxides, sec-alcohols, beta-lactams, benzoins, flavanones and epoxides. The experimental results showed excellent performances for enantioseparation, and highlighted that enantioseparation on homochiral MOF columns is practical.

引用

页码：21293 / 21301

页数：9

共 50 条

[21] Enantioseparation Using Chitosan Tris(3-chlorophenylcarbamate) as a Chiral Stationary Phase for HPLC
Xiaoqian Han
Lili An
Hong Cui
Hongyu Li
Wanliang Liu
Chromatographia, 2011, 73 : 1043 - 1047
[22] HPLC Enantioseparation of β-Blockers on Ovomucoid Stationary Phase
Imre, Silvia
Ormenisan, Anca
Tero-Vescan, Amelia
Muntean, Daniela-Lucia
Vari, Camil-Eugen
JOURNAL OF CHROMATOGRAPHIC SCIENCE, 2016, 54 (09) : 1578 - 1583
[23] Enantioseparation of novel chiral tetrahedrane-type clusters on a cellulose tris(3,5-dimethylphenylcarbamate) chiral stationary phase by HPLC
Li, WZ
Zhang, WQ
Li, YM
Dou, JM
Yin, YQ
Chen, LR
ACTA CHIMICA SINICA, 2004, 62 (16) : 1565 - 1568
[24] Efficient HPLC enantiomer separation using a pillared homochiral metal-organic framework as a novel chiral stationary phase
Tanaka, Koichi
Hotta, Naoki
Nagase, Shohei
Yoza, Kenji
NEW JOURNAL OF CHEMISTRY, 2016, 40 (06) : 4891 - 4894
[25] Comparative HPLC enantioseparation on substituted phenylcarbamoylated cyclodextrin chiral stationary phases and mobile phase effects
Lin, Chun
Fan, Jun
Liu, Wen-na
Tan, Yi
Zhang, Wei-guang
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 98 : 221 - 227
[26] Studies on the effect of alcohols on the chiral discrimination mechanisms of amylose stationary phase on the enantioseparation of nebivolol by HPLC
Aboul-Enein, HY
Ali, I
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 2001, 48 (02): : 175 - 188
[27] Enantioseparation of Eight Pairs of Tetralone Derivative Enantiomers on Cellulose Based Chiral Stationary Phase by HPLC
Zhang, Qiongwen
Zhang, Junyuan
Wang, Xia
Yu, Jia
Guo, Xingjie
CURRENT PHARMACEUTICAL ANALYSIS, 2020, 16 (05) : 539 - 547
[28] Preparation of a novel bridged bis(β-cyclodextrin) chiral stationary phase by thiol-ene click chemistry for enhanced enantioseparation in HPLC
Zhang, Ning
Guo, Siyu
Gong, Bolin
RSC ADVANCES, 2021, 11 (57) : 35754 - 35764
[29] Enantioseparation of Novel Chiral Tetrahedral Clusters on a Chiral Stationary Phase (CSP) by High Performance Liquid Chromatography
WANG Xia LI Wenzhi LIU Chunhui CHEN Liren LI Yongmin Lanzhou Institute of Chemical Physics The Chinese Academy of Sciences Lanzhou China Chemistry and Chemical Engineer College Liaocheng University Liaocheng China
不详
色谱, 2004, (04) : 329 - 330
[30] Chiral covalent organic framework core-shell composite CTpBD@SiO2 used as stationary phase for HPLC enantioseparation
Guo, Ping
Yuan, Bao-Yan
Yu, Yun-Yan
Zhang, Jun-Hui
Wang, Bang-Jin
Xie, Sheng-Ming
Yuan, Li-Ming
MICROCHIMICA ACTA, 2021, 188 (09)

← 1 2 3 4 5 →